Trial reportBMJ (Clinical research ed.)2015
Sacrospinous hysteropexy versus vaginal hysterectomy with suspension of the uterosacral ligaments in women with uterine prolapse stage 2 or higher: multicentre randomised non-inferiority trial.
Trial report in BMJ (Clinical research ed.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 6 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- Effect of different surgical techniques on postoperative wound infection in patients with uterine prolapse: A meta-analysis.International wound journal · 2024Pooled it
- Surgery for women with apical vaginal prolapse.The Cochrane database of systematic reviews · 2023Pooled it
- A systematic review of the surgical management of apical pelvic organ prolapse.International urogynecology journal · 2023Pooled it
- Sacrospinous hysteropexy: review and meta-analysis of outcomes.International urogynecology journal · 2017Pooled it
- Surgery for women with apical vaginal prolapse.The Cochrane database of systematic reviews · 2016Pooled it
- Biopsychosocial profile of women with pelvic organ prolapse: A systematic review.Women's health (London, England)Pooled it
- Economic evaluation of Manchester procedure versus sacrospinous hysteropexy: A follow-up analysis of a randomized clinical trial.PloS one · 2025Trial
- Trial
- Effect of sacrospinous hysteropexy with graft vs vaginal hysterectomy with uterosacral ligament suspension on treatment failure in women with uterovaginal prolapse: 5-year results of a randomized clinical trial.American journal of obstetrics and gynecology · 2021Trial
- Fast track sacrospinous ligament fixation: subjective and objective outcomes at 6 months.BMC women's health · 2021Trial
- Trial
- Patient Risk Factors for Incidental Pathology After Uterovaginal Surgery for Apical Prolapse: Systematic Review and Global Expert Consensus Statements.International urogynecology journal · 2026Review
- Environmental Impact of a Vaginal Pelvic Organ Prolapse Procedure: A Life Cycle Assessment with Scenario Modelling of Mitigation Strategies.International urogynecology journal · 2026Article
- Sacrospinous Hysteropexy Versus Vaginal Hysterectomy in Women with Uterine Prolapse: 10-year Follow-up of a Randomised Controlled Trial.International urogynecology journal · 2026Article
- Uterine preservation in pelvic organ prolapse.Gynecology and pelvic medicine · 2026Review
- Sacrospinous Ligament Fixation After Failed Sacrocolpopexy: A Case Series.Clinical case reports · 2025Article
- Surgical retreatment after native-tissue apical prolapse surgery with hysterectomy vs hysteropexy.American journal of obstetrics and gynecology · 2025Article
- [Vaginal pelvic floor reconstruction techniques].Urologie (Heidelberg, Germany) · 2025Review
- Article
- Long-Term Outcomes (10 Years) of Sacrospinous Ligament Fixation for Pelvic Organ Prolapse Repair.Healthcare (Basel, Switzerland) · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether uterus preserving vaginal sacrospinous hysteropexy is non-inferior to vaginal hysterectomy with suspension of the uterosacral ligaments in the surgical treatment of uterine prolapse.
designMulticentre randomised controlled non-blinded non-inferiority trial.
setting4 non-university teaching hospitals, the Netherlands.
participants208 healthy women with uterine prolapse stage 2 or higher requiring surgery and no history of pelvic floor surgery.
interventionsTreatment with sacrospinous hysteropexy or vaginal hysterectomy with suspension of the uterosacral ligaments. The predefined non-inferiority margin was an increase in surgical failure rate of 7%.
main outcome measuresPrimary outcome was recurrent prolapse stage 2 or higher of the uterus or vaginal vault (apical compartment) evaluated by the pelvic organ prolapse quantification system in combination with bothersome bulge symptoms or repeat surgery for recurrent apical prolapse at 12 months' follow-up. Secondary outcomes were overall anatomical recurrences, including recurrent anterior compartment (bladder) and/or posterior compartment (bowel) prolapse, functional outcome, complications, hospital stay, postoperative recovery, and sexual functioning.
resultsSacrospinous hysteropexy was non-inferior for anatomical recurrence of the apical compartment with bothersome bulge symptoms or repeat surgery (n=0, 0%) compared with vaginal hysterectomy with suspension of the uterosacral ligaments (n=4, 4.0%, difference -3.9%, 95% confidence interval for difference -8.6% to 0.7%). At 12 months, overall anatomical recurrences, functional outcome, quality of life, complications, hospital stay, measures on postoperative recovery, and sexual functioning did not differ between the two groups. Five serious adverse events were reported during hospital stay. None was considered to be related to the type of surgery.
conclusionsUterus preservation by sacrospinous hysteropexy was non-inferior to vaginal hysterectomy with suspension of the uterosacral ligaments for surgical failure of the apical compartment at 12 months' follow-up.
trial registrationtrialregister.nl NTR1866.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.