ArticleSurgery today2016
Novel approach to pleurodesis with 50 % glucose for air leakage after lung resection or pneumothorax.
Article in Surgery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07548047 (Dextrose Pleurodesis Versus Standard of Care for the Management of Post-Operative Air Leak), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dextrose Pleurodesis Versus Standard of Care for the Management of Post-Operative Air Leak: A Single Center Prospective Trial
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for the Treatment of Postoperative Air Leak After Lung Resections: A Prospective Randomized Controlled Study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Trial
- Effectiveness of free pericardial fat pad reinforcement for air leak control in pulmonary lobectomy.General thoracic and cardiovascular surgery · 2026Article
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- Article
- Autologous Blood Versus Talc Pleurodesis and the Influence of Non-steroidal Anti-inflammatory Drugs.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Pleurodesis using 50% glucose solution for air leak after pulmonary resection: a multi-center retrospective study.Surgery today · 2025Article
- Bone union achieved in an ulnar shaft nonunion using dextrose prolotherapy without surgery: a case report.Journal of surgical case reports · 2025Article
- Effective Management of Refractory Hepatic Hydrothorax With Hypertonic Glucose Pleurodesis.Cureus · 2025Article
- Efficacy of fibrin sealant for bedside pleurodesis in patients with prolonged air leak after lung cancer surgery: a comparative study.Frontiers in surgery · 2025Article
- Advancements in the Management of Postoperative Air Leak following Thoracic Surgery: From Traditional Practices to Innovative Therapies.Medicina (Kaunas, Lithuania) · 2024Review
- A Comparison of the Efficacies of OK-432 and Talc Slurry for Pleurodesis in Patients with Prolonged Air Leak after Pulmonary Resection.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2024Article
- Efficacy and safety of intraoperative partial spray of 50% glucose for patients with spontaneous pneumothorax.Journal of cardiothoracic surgery · 2024Article
- Early Pleurodesis for Postoperative Air Leak with Autologous Blood and 50% Glucose Solution.Journal of chest surgery · 2023Article
- Comparison between pleurodesis results by 50% glucose solution, versus Bleomycin pleurodesis in patients with malignant pleural effusion.International journal of physiology, pathophysiology and pharmacology · 2023Article
- Efficacy of Intraoperative Hypertonic Glucose Solution Administration on Persistent Air Leak After Extended Pleurectomy/Decortication for Malignant Pleural Mesothelioma: A Retrospective Case-Control Study.Frontiers in oncology · 2021Article
- Risk factors of postoperative recurrence of primary spontaneous pneumothorax.Journal of thoracic disease · 2020Article
- A deep azygoesophageal recess may increase the risk of secondary spontaneous pneumothorax.Surgery today · 2017Article
- Relatively Safer and Efficient Pleurodesis With 50% DW for Very Elderly Patients With Secondary Spontaneous Pneumothorax: Report of 2 Cases.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePleurodesis is performed in patients demonstrating air leakage after lung resection and in those with pneumothorax who must avoid surgery. However, there have so far been very few reports of pleurodesis with 50 % glucose. We herein examined the feasibility and effectiveness of this novel pleurodesis technique.
methodsThirty-five patients after lung resection and 11 pneumothorax patients without surgery were treated with pleurodesis using 50 % glucose. Approximately, 200 mL of 50 % glucose solution was injected into the pleural space and repeated until the air leakage stopped. Cases in which the air leakage did not stop after three injections were considered to be unsuccessful and subsequently treated with conventional pleurodesis using OK-432.
resultsThirty-nine patients were successfully treated with 50 % glucose, although 7 patients required further treatment with OK-432. The unsuccessful group had some pulmonary comorbidities (P < 0.001), and the pleural effusion volume after pleurodesis was less than that in the successful group (P < 0.001). Although the air leakage did not stop in unsuccessful patients, the amount of air leakage markedly decreased. A temporary elevation of the blood sugar level was observed in 20 patients, but no other side effects had appeared.
conclusionsPleurodesis with 50 % glucose is an easy, safe, and effective treatment modality. It is therefore considered to be a useful alternative method for pleurodesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.