ArticleAge (Dordrecht, Netherlands)2015
Fatiguing exercise initiated later in life reduces incidence of fibrillation and improves sleep quality in Drosophila.
Article in Age (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Exercise ModulatesInternational journal of molecular sciences · 2026Article
- Physical activity and sleep quality: exploring the mediating role of depression and the moderating role of physical fitness among adolescents.BMC public health · 2026Observational
- Unpredictable disturbance and its effects on activity behavior and lifespan in Drosophila melanogaster.Biology open · 2025Article
- Adipose Tissue Exosome circ_sxc Mediates the Modulatory of Adiposomes on Brain Aging by Inhibiting Brain dme-miR-87-3p.Molecular neurobiology · 2024Article
- Cardiac Timeless Trans-Organically Regulated by miR-276 in Adipose Tissue Modulates Cardiac Function.Function (Oxford, England) · 2024Article
- The relationship between physical activity and anxiety in college students: exploring the mediating role of lifestyle habits and dietary nutrition.Frontiers in psychology · 2024Article
- Regular Exercise Modulates theInternational journal of molecular sciences · 2023Article
- Role of muscle FOXO gene in exercise against the skeletal muscle and cardiac age-related defects and mortality caused by high-salt intake in Drosophila.Genes & nutrition · 2023Article
- Stable Expression of dmiR-283 in the Brain Promises Positive Effects in Endurance Exercise on Sleep-Wake Behavior in AgingInternational journal of molecular sciences · 2023Article
- Regular Exercise Rescues Heart Function Defects and Shortens the Lifespan ofInternational journal of environmental research and public health · 2022Article
- Early life exercise training and inhibition ofAging · 2022Article
- Exercise Training Upregulates CardiacBiology · 2022Article
- Exercise and/or Cold Exposure Alters the Gene Expression Profile in the Fat Body and Changes the Heart Function inFrontiers in endocrinology · 2022Article
- Exercise and the Brain: Lessons From Invertebrate Studies.Frontiers in behavioral neuroscience · 2022Review
- Review
- Exercise-induced changes in climbing performance.Royal Society open science · 2021Article
- GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise.Scientific reports · 2021Article
- Exercise-Training Regulates Apolipoprotein B inFrontiers in physiology · 2021Article
- Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NADBiology open · 2019Article
- The activation of cardiacAging · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the human body ages, the risk of heart disease and stroke greatly increases. While there is evidence that lifelong exercise is beneficial to the heart's health, the effects of beginning exercise later in life remain unclear. This study aimed to investigate whether exercise training started later in life is beneficial to cardiac aging in Drosophila. We examined 4-week-old wild-type virgin female flies that were exposed to exercise periods of either 1.5, 2.0, or 2.5 h per day, 5 days a week for 2 weeks. Using M-mode traces to analyze cardiac function by looking at parameters including heart rate, rhythmicity, systolic and diastolic diameter, and interval and fractional shortening, we found that cardiac function declined with age, shown by an increase in the number of fibrillation events and a decrease in fractional shortening. About 2.0 and 2.5 h of exercise per day displayed a reduced incidence of fibrillation events, and only physical exercise lasting 2.5-h period increased fractional shortening and total sleep time in Drosophila. These data suggested that training exercise needs to be performed for longer duration to exert physiological benefits for the aging heart. Additionally, climbing ability to assess the exercise-induced muscle fatigue was also measured. We found that 2.0 and 2.5 h of exercise caused exercise-induced fatigue, and fatiguing exercise is beneficial for cardiac and healthy aging overall. This study provides a basis for further study in humans on the impact of beginning an exercise regimen later in life on cardiac health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.