Evidence map›Paper›PMID 26206347›Full record

ArticleInternational journal of colorectal disease2015

Genome-wide copy number changes and CD133 expression characterized distinct subset of colon polyps: differentiation between incidental polyps and cancer-associated polyps.

Chih-Yung Yang, Ju-Yu Tseng, Chian-Feng Chen, Teh-Ying Chou, Hong-Wei Gao, Chia-Ling Hua, Chi-Hung Lin, Jen-Kou Lin, Jeng-Kai Jiang

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In one paragraph

Article in International journal of colorectal disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. ARE STEM CELL MARKER EXPRESSION AND CD133 ANALYSIS RELEVANT TO DIFFERENTIATE COLORECTAL CANCER?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021
    Article
  2. IS THERE A CLINICAL PATHOLOGICAL CORRELATION OF COLORECTAL ADENOCARCINOMA WITH THE IMMUNOHISTOCHEMICAL EXPRESSION OF OPN AND ABCB5?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021
    Article
  3. ARE STEM CELL MARKER EXPRESSION AND CD133 ANALYSIS RELEVANT TO DIFFERENTIATE COLORECTAL CANCER?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021
    Article
  4. Article
  5. New insights into the earliest stages of colorectal tumorigenesis.Expert review of gastroenterology & hepatology · 2017
    Review
  6. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Chih-Yung YangDepartment of Education and Research, Taipei City Hospital, Taipei, Taiwan.
Ju-Yu TsengInstitute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan.
Chian-Feng ChenVYM Genome Research Center, National Yang-Ming University, Taipei, Taiwan.
Teh-Ying ChouDepartment of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan.
Hong-Wei GaoDepartment of Pathology, Tri-Service General Hospital, Taipei, Taiwan.
Chia-Ling HuaVYM Genome Research Center, National Yang-Ming University, Taipei, Taiwan.
Chi-Hung LinDepartment of Education and Research, Taipei City Hospital, Taipei, Taiwan.
Jen-Kou LinSchool of Medicine, National Yang-Ming University, Taipei, Taiwan.
Jeng-Kai JiangSchool of Medicine, National Yang-Ming University, Taipei, Taiwan. jkjiang@vghtpe.gov.tw.
National Yang Ming Chiao Tung University · TWNational Yang Ming Chiao Tung University · TWTaipei City Hospital · TWTaipei Veterans General Hospital · TWTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeColorectal polyps are generally believed to be the precursors of colorectal cancers (CRC); however, the proportion and speed of progression differed widely in different subsets of polyps. Using microarray-based comparative genomic hybridization (aCGH) platform and CD133 immunostaining, we characterized colon polyps according to their association with CRC that developed in the same individual. PATIENTS AND

methodsaCGH was performed to unveil genomic changes in 18 cancer-synchronous polyps (CSP), and 9 cancer-preceding polyps (CPP), together with their corresponding cancers and 16 cases of incidental polyps (IP), were examined for comparison. aCGH profiles were analyzed to determine the clonal relationship (CR) between the paired adenoma and carcinoma. CD133 expressions in each subset of polyps were quantified by immunohistochemistry (IHC) staining.

resultsProgressive genomic changes were observed from IP, CSP/CPP to CRC; they encompass an entire chromosomal region in IP and sub-chromosomal region in CSP/CPP and CRC. CR analyses demonstrated that 50 % of CSP and 67 % of CPP were clonally related to the concurrent or later developed carcinomas, respectively. The CD133 expression levels were significantly higher in CSP/CPP than those in IP (P < 0.0001) and even higher in CSP/CPP that were clonally related to their corresponding carcinomas than CSP/CPP that were unrelated (P < 0.05).

conclusionsThere were more genomic changes in CSP/CPP than IP; more than half of the CSP/CPP were clonally related to the corresponding carcinomas. Genomic changes at sub-chromosomal regions and/or high CD133 expression were associated with CSP/CPP and highlighted their carcinogenic potential.

Indexed as

AC133 AntigenAdenomaAgedAged, 80 and overAntigens, CDCarcinomaColonic PolypsComparative Genomic HybridizationFemaleGene ExpressionGlycoproteinsHumansImmunohistochemistryMaleMiddle AgedPeptidesAC133 AntigenAntigens, CDGlycoproteinsPeptidesPROM1 protein, humanArray CGHCD133Colorectal cancerColorectal polyp

Identifiers

PMID26206347
OpenAlexW2100594643

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.