Evidence map›Paper›PMID 26206261›Full record

ArticleInternational orthopaedics2015

Collagen type I coating stimulates bone regeneration and osteointegration of titanium implants in the osteopenic rat.

Maria Sartori, Gianluca Giavaresi, Annapaola Parrilli, Andrea Ferrari, Nicolò Nicoli Aldini, Marco Morra, Clara Cassinelli, Daniele Bollati, Milena Fini

Abstract read
PubMed Publisher
In one paragraph

Article in International orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Maria SartoriLaboratory of Biocompatibility, Technological Innovations and Advanced Therapies, RIT Department, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy. maria.sartori@ior.it.
Gianluca GiavaresiLaboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy.
Annapaola ParrilliLaboratory of Biocompatibility, Technological Innovations and Advanced Therapies, RIT Department, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy.
Andrea FerrariLaboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy.
Nicolò Nicoli AldiniLaboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy.
Marco MorraNobil Bio Ricerche SRL, Via Valcastellana 26, 14037, Portacomaro d'Asti, AT, Italy.
Clara CassinelliNobil Bio Ricerche SRL, Via Valcastellana 26, 14037, Portacomaro d'Asti, AT, Italy.
Daniele BollatiNobil Bio Ricerche SRL, Via Valcastellana 26, 14037, Portacomaro d'Asti, AT, Italy.
Milena FiniLaboratory of Biocompatibility, Technological Innovations and Advanced Therapies, RIT Department, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, 40136, Bologna, Italy.
Istituto Ortopedico Rizzoli · ITAzienda Sanitaria Locale di Asti · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effects of titanium implants functionalised with collagen type I (TiColl) on bone regeneration and osteointegration in a healthy and osteopenic rat animal model.

methodTiColl screws were implanted into the femoral condyles of healthy and osteopenic rats and compared with acid-etched titanium (Ti) screws. The osteointegration process was evaluated by a complementary approach combining microtomographic, histological, histomorphometric and biomechanical investigations at four and 12 weeks.

resultsThe TiColl screw also ensured a greater mechanical stability; the push-out values for TiColl screws increased from four to 12 weeks (+28 %). The energy necessary to detach the bone from the screw was significantly higher for TiColl-functionalised screws in comparison to Ti screws (+23 %) at 12 weeks. Histomorphometric investigation revealed that total bone-to-implant contact was higher in TiColl screws in comparison to Ti screws (P < 0.05) and at epiphyseal level, increased bone-to-implant contact was found with TiColl screws in comparison to Ti screws (P < 0.05) in an ovariectomy (OVX) condition. A significant increase in the measured total bone ingrowth from four to 12 weeks was detected for both materials, but more significant for the TiColl material (P < 0.0005). Finally, bone ingrowth in the TiColl group was significantly higher (P < 0.005) in comparison to that of Ti screws in the SHAM condition at metaphyseal level at 12 weeks.

conclusionThe present results showed that TiColl is effective in promoting implant osteointegration even in compromised bone.

Indexed as

AnimalsBone Diseases, MetabolicBone RegenerationBone ScrewsCoated Materials, BiocompatibleCollagen Type IDisease Models, AnimalFemaleFemurHumansOsseointegrationProsthesis DesignRatsRats, Sprague-DawleyTitaniumCoated Materials, BiocompatibleCollagen Type ITitaniumCollagen type IImplantsOsteointegrationOsteopenic condition

Identifiers

PMID26206261
OpenAlexW1410919618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.