ArticleGenome research2015
Identifying genomic changes associated with insecticide resistance in the dengue mosquito Aedes aegypti by deep targeted sequencing.
Article in Genome research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 187 citations in OpenAlex.
- Emerging and regionally novel voltage-gated sodium channel mutations associated with pyrethroid resistance and altered binding affinity in Aedes albopictus (Skuse) from Northern Peninsular Malaysia.Parasites & vectors · 2026Article
- Integrated transcriptomic and variant analysis reveals molecular mechanisms of pyrethroid resistance in a genetically homogenized Cas9 strain of Aedes aegypti.Archives of toxicology · 2026Article
- Metabolic resistance of the tiger mosquito to pyrethroid insecticides in La Réunion Island likely results from local adaptation.Genome biology and evolution · 2026Article
- Current Knowledge on Insecticide Resistance inInsects · 2026Review
- PoolSeq Genome-Wide Association Studies and Microbial Signature Analyses Identify Novel Candidates Associated With Pyrethroid Resistance Evolution in Anopheles funestus in Cameroon.Molecular ecology · 2026Article
- Standing genetic variation underlies divergence of nicotinic acetylcholine receptor subunits among cryptic species of thebioRxiv : the preprint server for biology · 2025Article
- Insecticide resistance levels, spatial distribution, and kdr mutations in the dengue vector Aedes albopictus of Hong Kong.PLoS neglected tropical diseases · 2025Article
- Pyrethroid resistance in Aedes aegypti: genetic mechanisms worldwide, and recommendations for effective vector control.Parasites & vectors · 2025Review
- Genomics of urban adaptation and exaptation in mosquitoes and consequences for vectorial capacity.Current opinion in insect science · 2025Review
- The southern house mosquito Culex quinquefasciatus in Abu Dhabi, UAE, is developing resistance to deltamethrin insecticide.Scientific reports · 2025Article
- Uncovering the genetic diversity in Aedes aegypti insecticide resistance genes through global comparative genomics.Scientific reports · 2024Article
- Article
- Potential of MALDI-TOF MS biotyping to detect deltamethrin resistance in the dengue vector Aedes aegypti.PloS one · 2024Article
- De novo genome assembly of the invasive mosquito species Aedes japonicus and Aedes koreicus.Parasites & vectors · 2023Article
- Article
- Advances in the genetic characterization of the malaria vector, Anopheles funestus, and implications for improved surveillance and control.Malaria journal · 2023Review
- A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bugEvolutionary applications · 2023Article
- Strong Positive Selection in Aedes aegypti and the Rapid Evolution of Insecticide Resistance.Molecular biology and evolution · 2023Article
- Status Quo and Future Perspectives of Molecular and Genomic Studies on the GenusInternational journal of molecular sciences · 2023Review
- The duplicated P450s CYP6P9a/b drive carbamates and pyrethroids cross-resistance in the major African malaria vector Anopheles funestus.PLoS genetics · 2023Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capacity of mosquitoes to resist insecticides threatens the control of diseases such as dengue and malaria. Until alternative control tools are implemented, characterizing resistance mechanisms is crucial for managing resistance in natural populations. Insecticide biodegradation by detoxification enzymes is a common resistance mechanism; however, the genomic changes underlying this mechanism have rarely been identified, precluding individual resistance genotyping. In particular, the role of copy number variations (CNVs) and polymorphisms of detoxification enzymes have never been investigated at the genome level, although they can represent robust markers of metabolic resistance. In this context, we combined target enrichment with high-throughput sequencing for conducting the first comprehensive screening of gene amplifications and polymorphisms associated with insecticide resistance in mosquitoes. More than 760 candidate genes were captured and deep sequenced in several populations of the dengue mosquito Ae. aegypti displaying distinct genetic backgrounds and contrasted resistance levels to the insecticide deltamethrin. CNV analysis identified 41 gene amplifications associated with resistance, most affecting cytochrome P450s overtranscribed in resistant populations. Polymorphism analysis detected more than 30,000 variants and strong selection footprints in specific genomic regions. Combining Bayesian and allele frequency filtering approaches identified 55 nonsynonymous variants strongly associated with resistance. Both CNVs and polymorphisms were conserved within regions but differed across continents, confirming that genomic changes underlying metabolic resistance to insecticides are not universal. By identifying novel DNA markers of insecticide resistance, this study opens the way for tracking down metabolic changes developed by mosquitoes to resist insecticides within and among populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.