ArticleJournal of neurochemistry2015
Alzheimer's disease and modern lifestyle: what is the role of stress?
Article in Journal of neurochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- The Double-Edged Effects of Substance P in the Pathology of Alzheimer's Disease.Aging and disease · 2024Review
- Mortality Trends in Alzheimer's Disease in Mississippi, 2011-2021.Diseases (Basel, Switzerland) · 2023Review
- Leveraging Technology to Diagnose Alzheimer's Disease: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Review
- Leveraging mHealth and Virtual Reality to Improve Cognition for Alzheimer's Patients: A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- Association between Physical Activity and Cognitive Function among the Elderly in the Health and Social Centers in Kenitra, Rabat, and Sidi Kacem City (Morocco).Nutrition and metabolic insights · 2021Article
- Life-Course Contribution of Prenatal Stress in Regulating the Neural Modulation Network Underlying the Prepulse Inhibition of the Acoustic Startle Reflex in Male Alzheimer's Disease Mice.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Gestational Stress Augments Postpartum β-Amyloid Pathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress.Neurobiology of stress · 2018Review
- Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration.Frontiers in cellular neuroscience · 2017Review
- Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function.Scientific reports · 2016Article
- Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Tauopathy in transgenic (SHR72) rats impairs function of central noradrenergic system and promotes neuroinflammation.Journal of neuroinflammation · 2016Article
- Inhibition of ACE Retards Tau Hyperphosphorylation and Signs of Neuronal Degeneration in Aged Rats Subjected to Chronic Mild Stress.BioMed research international · 2015Article
- Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health.Alzheimer disease and associated disordersArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This Editorial highlights a study by Baglietto-Vargas et al. 2015 published in this issue of J. Neurochem. Stress is one of the environmental factors that can contribute to Alzheimer's disease pathogenesis. However, the role of modern-life stress has not been investigated yet. The authors reveal that modern-life stress reduces the number of dendritic spines in the hippocampus of Alzheimer's disease transgenic mice. The mechanism underlying such effect involves an increase in corticotropin-releasing hormone (CRH) release that stimulates the amyloid precursor protein (APP) processing and fosters the generation of Amyloid-β, which negatively affects dendritic spines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.