ArticleGenetics2015
Do Molecular Markers Inform About Pleiotropy?
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models.European journal of human genetics : EJHG · 2017Pooled it
- Estimating genetic correlation jointly using individual-level and summary-level GWAS data.Nature communications · 2026Article
- Mycogenic Fabrication of Zinc Nanoparticles for Their Antifungal Activity AgainstIndian journal of microbiology · 2025Article
- Genotype-based "virtual" metabolomics in a clinical biobank identifies novel metabolite-disease associations.Frontiers in genetics · 2024Article
- Genotype-based "virtual" metabolomics in a clinical biobank identifies novel metabolite-disease associations.Research square · 2023Article
- Diet can alter the cost of resistance to a natural parasite inEcology and evolution · 2023Article
- Pleiotropy Structures Plant Height and Seed Weight Scaling in Barley despite Long History of Domestication and Breeding Selection.Plant phenomics (Washington, D.C.) · 2023Article
- Application of Bayesian genomic prediction methods to genome-wide association analyses.Genetics, selection, evolution : GSE · 2022Review
- Genetic Modeling and Genomic Analyses of Yearling Temperament in American Angus Cattle and Its Relationship With Productive Efficiency and Resilience Traits.Frontiers in genetics · 2022Article
- Mapping pleiotropic loci using a fast-sequential testing algorithm.European journal of human genetics : EJHG · 2021Article
- Genetic correlations between traits associated with hyperuricemia, gout, and comorbidities.European journal of human genetics : EJHG · 2021Article
- Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection.Human genetics · 2021Article
- Emerging issues in genomic selection.Journal of animal science · 2021Article
- A Systematic Review of Genomic Regions and Candidate Genes Underlying Behavioral Traits in Farmed Mammals and Their Link with Human Disorders.Animals : an open access journal from MDPI · 2021Review
- Novel Bayesian Networks for Genomic Prediction of Developmental Traits in Biomass Sorghum.G3 (Bethesda, Md.) · 2020Article
- A Multiple-Trait Bayesian Lasso for Genome-Enabled Analysis and Prediction of Complex Traits.Genetics · 2020Article
- Marker Selection in Multivariate Genomic Prediction Improves Accuracy of Low Heritability Traits.Frontiers in genetics · 2020Article
- How Well Can Multivariate and Univariate GWAS Distinguish Between True and Spurious Pleiotropy?Frontiers in genetics · 2020Article
- Genomic Bayesian Confirmatory Factor Analysis and Bayesian Network To Characterize a Wide Spectrum of Rice Phenotypes.G3 (Bethesda, Md.) · 2019Article
- Simultaneous selection for grain yield and protein content in genomics-assisted wheat breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The availability of dense panels of common single-nucleotide polymorphisms and sequence variants has facilitated the study of statistical features of the genetic architecture of complex traits and diseases via whole-genome regressions (WGRs). At the onset, traits were analyzed trait by trait, but recently, WGRs have been extended for analysis of several traits jointly. The expectation is that such an approach would offer insight into mechanisms that cause trait associations, such as pleiotropy. We demonstrate that correlation parameters inferred using markers can give a distorted picture of the genetic correlation between traits. In the absence of knowledge of linkage disequilibrium relationships between quantitative or disease trait loci and markers, speculating about genetic correlation and its causes (e.g., pleiotropy) using genomic data is conjectural.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.