Evidence map›Paper›PMID 26205896›Full record

ArticleBMC geriatrics2015

Positive correlation of serum adipocyte fatty acid binding protein levels with carotid-femoral pulse wave velocity in geriatric population.

Jen-Pi Tsai, Ji-Hung Wang, Chung-Jen Lee, Yu-Chih Chen, Bang-Gee Hsu

Open access · goldAbstract read
In one paragraph

Article in BMC geriatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Adipokines and Arterial Stiffness in Obesity.Medicina (Kaunas, Lithuania) · 2021
    Review
  5. Article
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  8. Serum sclerostin as an independent marker of peripheral artery disease in elderly persons.International journal of clinical and experimental pathology · 2018
    Article
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jen-Pi TsaiDivision of Nephrology, Buddhist Tzu Chi General Hospital, Dalin Branch, Chia-Yi, Taiwan. abi0918@outlook.com.
Ji-Hung WangSchool of Medicine, Tzu Chi University, Hualien, Taiwan. jihung-wang@tzuchi.com.tw.
Chung-Jen LeeDepartment of Nursing, Tzu Chi College of Technology, Hualien, Taiwan. guggilee@msn.com.
Yu-Chih ChenDivision of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. michaelchen@tzuchi.com.tw.
Bang-Gee HsuSchool of Medicine, Tzu Chi University, Hualien, Taiwan. gee.lily@msa.hinet.net.
Buddhist Tzu Chi General Hospital · TWTzu Chi University · TWTzu Chi College of Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdipocyte fatty acid binding protein (A-FABP) is a novel fat-derived circulating protein, which is independently and positively associated with atherosclerosis. The present study evaluated the relationship between fasting serum A-FABP and central arterial stiffness in geriatric adults.

methodsFasting blood samples were obtained from 87 geriatric patients and the serum A-FABP levels were measured using an enzyme immunoassay. Carotid-femoral pulse wave velocity (cfPWV) was determined using the SphygmoCor system. cfPWV values of >10 m/s represented the high arterial stiffness group, while values ≤10 m/s defined the low arterial stiffness group.

resultsHigh arterial stiffness group comprised of 42 geriatric adults (48.3%). When compared to those in the low arterial stiffness group, the high arterial stiffness group had a higher rate of diabetes mellitus (P = 0.044) and hypertension (P = 0.043). Body weight (P = 0.027), waist circumference (P = 0.035), body mass index (P = 0.001), systolic blood pressure (P = 0.005), diastolic blood pressure (P = 0.045), pulse pressure (P = 0.038), and serum A-FABP level (P < 0.001) were also higher in the high arterial stiffness group than in the low arterial stiffness group. Multivariate logistic regression analysis of the factors significantly associated with arterial stiffness revealed that A-FABP (odds ratio: 1.833, 95% confidence interval 1.123-2.993, P = 0.015) was an independent predictor of arterial stiffness in geriatric adults.

conclusionsSerum A-FABP levels constitute a major risk factor in the development of central arterial stiffness in the geriatric population.

Indexed as

AtherosclerosisAgedAged, 80 and overAgingBlood PressureBody Mass IndexCarotid ArteriesFatty Acid-Binding ProteinsFemaleFemoral ArteryHumansMalePulse Wave AnalysisRisk FactorsStatistics as TopicVascular StiffnessFatty Acid-Binding Proteins

Identifiers

PMID26205896
PMCPMC4513955
OpenAlexW1486887841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.