ArticleBMC complementary and alternative medicine2015
In vitro biological action of aqueous extract from roots of Physalis angulata against Leishmania (Leishmania) amazonensis.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 44 citations in OpenAlex.
- Review
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- Exploration of Antileishmanial Compounds Derived from Natural Sources.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024Review
- In Vitro Leishmanicidal Activity of Copaiba Oil and Kojic Acid Combination on the ProtozoanMicroorganisms · 2023Article
- Activity of alkaloids from Aspidosperma nitidum against Leishmania (Leishmania) amazonensis.Scientific reports · 2022Article
- GC-MS screening and antiparasitic action ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Secure and Sustainable Sourcing of Plant Tissues for the Exhaustive Exploration of Their Chemodiversity.Molecules (Basel, Switzerland) · 2020Article
- Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasis.PLoS neglected tropical diseases · 2020Article
- Transcriptome-wide identification of microRNAs and functional insights inferred from microRNA-target pairs inPlant signaling & behavior · 2019Article
- Leishmanicidal Activity of (+)-Phyllanthidine and the Phytochemical Profile of Margaritaria nobilis (Phyllanthaceae).Molecules (Basel, Switzerland) · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeishmaniasis is an infectious disease caused by various species of the protozoan parasites of the Leishmania genus and transmitted by phlebotomine sandflies. The protozoa multiply in phagocytic cells, mainly macrophages, which play an important role defending the organism from pathogens. The most effective treatment for leishmaniasis is the chemotherapy and besides the high cost, these drugs are toxic and require a long period of treatment. Currently, some herbal products are considered an important alternative source of a new leishmanicidal agent, which includes the plant Physalis angulata, . We evaluated effects of an aqueous extract from roots of Physalis angulata (AEPa) on Leishmania proliferation, morphology and also determined whether physalins were present in the extract contributing to the knowledge of its pharmacological efficacy.
methodsMorphological alterations were determined by light microscopy, transmission and scanning electron microscopy. Host cell viability was evaluated by MTT, and propidium iodide. AEPa were submitted in full HRESITOF analysis.
resultsAEPa promoted a dose-dependent reduction on promastigotes (IC50 = 39.5 μg/mL ± 5.1) and amastigotes (IC50 = 43.4 μg/mL ± 10.1) growth. This growth inhibition was associated with several morphological alterations observed in promastigote forms. No cytotoxic effect in mammalian cells was detected (IC50 > 4000 μg/mL). Furthemore, the presence of physalins A, B, D, E, F, G and H were described, for the first time, in the P. angulata root.
conclusionsResults demonstrate that AEPa effectively promotes antileishmanial activity with several important morphological alterations and has no cytotoxic effects on host cells.
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