Evidence map›Paper›PMID 26205537›Full record

ArticleNature communications2015

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.

Valérie Soulard, Henriette Bosson-Vanga, Audrey Lorthiois, Clémentine Roucher, Jean-François Franetich, Gigliola Zanghi, Mallaury Bordessoulles, Maurel Tefit, Marc Thellier, Serban Morosan and 6 more

Abstract read
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In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Application of a Non-Targeted Metabolomics Study inInternational journal of molecular sciences · 2025
    Article
  11. Article
  12. Review
  13. Article
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  15. Article
  16. Mice Engrafted with Human Liver Cells.Seminars in liver disease · 2024
    Review
  17. Article
  18. IdentifyingResearch square · 2024
    Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Valérie Soulard1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Henriette Bosson-Vanga1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [4] Université FHB, UFR SPB, Departement de Parasitologie-Mycologie, BP V 34 Abidjan, Ivory Coast.
Audrey Lorthiois1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Clémentine Roucher1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Jean-François Franetich1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Gigliola Zanghi1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Mallaury Bordessoulles1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Maurel Tefit1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Marc ThellierAP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Centre National de Référence du Paludisme, 83 Bd de l'hôpital, F-75013 Paris, France.
Serban MorosanUPMC Univ. Paris 06, INSERM, UMS28, 105 Bd de l'hôpital, F-75013 Paris, France.
Gilles Le NaourAP-HP, UPMC Univ. Paris 06, Groupe Hospitalier Pitié-Salpêtrière, Service d'anatomie et cytologie pathologiques, 83 Bd de l'hôpital, F-75013 Paris, France.
Frédérique CapronAP-HP, UPMC Univ. Paris 06, Groupe Hospitalier Pitié-Salpêtrière, Service d'anatomie et cytologie pathologiques, 83 Bd de l'hôpital, F-75013 Paris, France.
Hiroshi SuemizuCentral Institute for Experimental Animal, Kawasaki, Kanegawa, Japan.
Georges Snounou1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Alicia Moreno-Sabater1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France.
Dominique Mazier1] Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, F-75013 Paris, France [2] INSERM, U1135, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [3] CNRS, ERL 8255, CIMI-PARIS, 91 Bd de l'hôpital, F-75013 Paris, France [4] AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Centre National de Référence du Paludisme, 83 Bd de l'hôpital, F-75013 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experimental studies of Plasmodium parasites that infect humans are restricted by their host specificity. Humanized mice offer a means to overcome this and further provide the opportunity to observe the parasites in vivo. Here we improve on previous protocols to achieve efficient double engraftment of TK-NOG mice by human primary hepatocytes and red blood cells. Thus, we obtain the complete hepatic development of P. falciparum, the transition to the erythrocytic stages, their subsequent multiplication, and the appearance of mature gametocytes over an extended period of observation. Furthermore, using sporozoites derived from two P. ovale-infected patients, we show that human hepatocytes engrafted in TK-NOG mice sustain maturation of the liver stages, and the presence of late-developing schizonts indicate the eventual activation of quiescent parasites. Thus, TK-NOG mice are highly suited for in vivo observations on the Plasmodium species of humans.

Indexed as

Disease Models, AnimalAnimalsErythrocyte TransfusionFemaleHepatocytesHumansLife Cycle StagesLiverMalariaMaleMice, TransgenicPlasmodium falciparumPlasmodium ovaleSporozoites

Identifiers

PMID26205537
PMCPMC4525212

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