Evidence map›Paper›PMID 26205346›Full record

ArticleLipids2015

Bis(monoacylglycero)phosphate as a Macrophage Enriched Phospholipid.

Zeynep Akgoc, Sonia Iosim, Thomas N Seyfried

Abstract read
PubMed Publisher
In one paragraph

Article in Lipids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

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  13. Life in the lumen: The multivesicular endosome.Traffic (Copenhagen, Denmark) · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zeynep AkgocBiology Department, Boston College, 140 Commonwealth Ave, MA, 02467, Chestnut Hill, USA, zeynepakgc@gmail.com.
Sonia Iosim
Thomas N Seyfried
Boston College · US

Funding

Glycosphingolipids in murine neurodegenerative diseasesR01NS055195 · NINDS · BOSTON COLLEGE · PI SEYFRIED, THOMAS N · 2006 to 2009
$1.5M
Glycosphingolipids in Murine Neurodegenerative DiseasesR56NS055195 · NINDS · BOSTON COLLEGE · PI SEYFRIED, THOMAS N · 2012 to 2012
$346k
NINDS NIH HHS NS-055195
6 · The paper itself

Abstract

Bis(monoacylglycero)phosphate (BMP) is a structural isomer of phosphatidylglycerol (PtdGro) with an unusual sn-1:sn-1' fatty acyl configuration and is found almost exclusively in late endosomes/lysosomes. BMP comprises only about 1-2% of the total phospholipids in most mammalian cells, but accumulates in tissues of humans and animals with lysosomal storage disorders including the gangliosidoses. Total BMP content was significantly greater in cells of macrophage/microglial origin than in cells of macroglial origin. BMP composition was similar in tumorigenic/metastatic macrophages and non-tumorigenic macrophages/microglia. Finally, BMP fatty acid composition differed between cells grown in culture and obtained in vivo suggesting an influence from growth environment.

Indexed as

AnimalsCell Line, TumorHumansLysophospholipidsMacrophagesMiceMonoglyceridesPhospholipidsbis(monoacylglyceryl)phosphateLysophospholipidsMonoglyceridesPhospholipids

Identifiers

PMID26205346
OpenAlexW1028330988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.