ReviewMolecules (Basel, Switzerland)2015
Secondary metabolites from Rubiaceae species.
Review in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
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- Interspecific and Environmental Influence on the Foliar Metabolomes ofPlants (Basel, Switzerland) · 2025Article
- A Review of Phytochemical and Pharmacological Studies onMolecules (Basel, Switzerland) · 2025Review
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- Chemical composition and anticancer activity of Psychotria montana on MCF7 breast cancer cells: insights from in vitro (2D & 3D) studies and in silico analysis.Journal of applied biomedicine · 2025Article
- Identification of Bioactive Metabolites ofMetabolites · 2025Article
- Unveiling the Pharmacological Promise ofBioMed research international · 2025Article
- Genome mining of metabolic gene clusters in the Rubiaceae family.Computational and structural biotechnology journal · 2024Article
- Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis.The Plant journal : for cell and molecular biology · 2024Article
- Review
- Antiviral Potential ofInternational journal of molecular sciences · 2024Article
- Identification, Characterization, and Antibacterial Evaluation of Five Endophytic Fungi fromMicroorganisms · 2024Article
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- Induction of Monoterpenoid Oxindole Alkaloids Production and Related Biosynthetic Gene Expression in Response to Signaling Molecules inPlants (Basel, Switzerland) · 2024Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study describes some characteristics of the Rubiaceae family pertaining to the occurrence and distribution of secondary metabolites in the main genera of this family. It reports the review of phytochemical studies addressing all species of Rubiaceae, published between 1990 and 2014. Iridoids, anthraquinones, triterpenes, indole alkaloids as well as other varying alkaloid subclasses, have shown to be the most common. These compounds have been mostly isolated from the genera Uncaria, Psychotria, Hedyotis, Ophiorrhiza and Morinda. The occurrence and distribution of iridoids, alkaloids and anthraquinones point out their chemotaxonomic correlation among tribes and subfamilies. From an evolutionary point of view, Rubioideae is the most ancient subfamily, followed by Ixoroideae and finally Cinchonoideae. The chemical biosynthetic pathway, which is not so specific in Rubioideae, can explain this and large amounts of both iridoids and indole alkaloids are produced. In Ixoroideae, the most active biosysthetic pathway is the one that produces iridoids; while in Cinchonoideae, it produces indole alkaloids together with other alkaloids. The chemical biosynthetic pathway now supports this botanical conclusion.
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