ArticleInfection control and hospital epidemiology2015
Modeling spread of KPC-producing bacteria in long-term acute care hospitals in the Chicago region, USA.
Article in Infection control and hospital epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
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- Active surveillance of carbapenemase-producing Enterobacterales using genomic sequencing for hospital-based infection control interventions.Infection control and hospital epidemiology · 2024Article
- Carbapenem-resistantOpen forum infectious diseases · 2024Article
- Genomic Epidemiology and Characterization of Carbapenem-Resistant Klebsiella pneumoniae in ICU Inpatients in Henan Province, China: a Multicenter Cross-Sectional Study.Microbiology spectrum · 2023Article
- Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2017-2021.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023Article
- Cost-effectiveness of strategies to control the spread of carbapenemase-producing Enterobacterales in hospitals: a modelling study.Antimicrobial resistance and infection control · 2022Article
- Threshold-free genomic cluster detection to track transmission pathways in health-care settings: a genomic epidemiology analysis.The Lancet. Microbe · 2022Article
- Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2016-2020.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022Article
- Case-case-control study of risk factors for carbapenem-resistant Enterobacterales infections among hospitalized patients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2022Article
- Dissemination mechanisms of NDM genes in hospitalized patients.JAC-antimicrobial resistance · 2021Article
- Transmission Dynamics of Clostridioides difficile in 2 High-Acuity Hospital Units.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Effectiveness of Contact Precautions to Prevent Transmission of Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci in Intensive Care Units.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Clinical and Microbiological Characterization of Carbapenem-ResistantFrontiers in pharmacology · 2021Article
- Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study.The Lancet. Infectious diseases · 2020Observational
- Extended models for nosocomial infection: parameter estimation and model selection.Mathematical medicine and biology : a journal of the IMA · 2018Article
- Efficiency of different control measures for preventing carbapenemase-producing enterobacteria and glycopeptide-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2018Article
- The Potential for Interventions in a Long-term Acute Care Hospital to Reduce Transmission of Carbapenem-Resistant Enterobacteriaceae in Affiliated Healthcare Facilities.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Modifiable Risk Factors for the Spread of Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Among Long-Term Acute-Care Hospital Patients.Infection control and hospital epidemiology · 2017Article
- Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?GMS hygiene and infection control · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivePrevalence of bla KPC-encoding Enterobacteriaceae (KPC) in Chicago long-term acute care hospitals (LTACHs) rose rapidly after the first recognition in 2007. We studied the epidemiology and transmission capacity of KPC in LTACHs and the effect of patient cohorting.
methodsData were available from 4 Chicago LTACHs from June 2012 to June 2013 during a period of bundled interventions. These consisted of screening for KPC rectal carriage, daily chlorhexidine bathing, medical staff education, and 3 cohort strategies: a pure cohort (all KPC-positive patients on 1 floor), single rooms for KPC-positive patients, and a mixed cohort (all KPC-positive patients on 1 floor, supplemented with KPC-negative patients). A data-augmented Markov chain Monte Carlo (MCMC) method was used to model the transmission process.
resultsAverage prevalence of KPC colonization was 29.3%. On admission, 18% of patients were colonized; the sensitivity of the screening process was 81%. The per admission reproduction number was 0.40. The number of acquisitions per 1,000 patient days was lowest in LTACHs with a pure cohort ward or single rooms for colonized patients compared with mixed-cohort wards, but 95% credible intervals overlapped.
conclusionsPrevalence of KPC in LTACHs is high, primarily due to high admission prevalence and the resultant impact of high colonization pressure on cross transmission. In this setting, with an intervention in place, patient-to-patient transmission is insufficient to maintain endemicity. Inclusion of a pure cohort or single rooms for KPC-positive patients in an intervention bundle seemed to limit transmission compared to use of a mixed cohort.
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