ArticlePLoS neglected tropical diseases2015
Application of wMelPop Wolbachia Strain to Crash Local Populations of Aedes aegypti.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 114 citations in OpenAlex.
- Research Trends and Collaborative Patterns inInternational journal of environmental research and public health · 2026Article
- The inhibition mechanism ofFrontiers in microbiology · 2026Review
- Effect of prolonged dehydration stress on the vector competence ofbioRxiv : the preprint server for biology · 2025Article
- Changes in the frequency of facultative endosymbionts in insect populations: overview and applications.Entomologia generalis · 2025Article
- Wolbachia elevates host methyltransferase expression and alters the mBMC microbiology · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- UnveilingFrontiers in cellular and infection microbiology · 2025Article
- Article
- Dehydration stress and Mayaro virus vector competence inJournal of virology · 2023Article
- Targeted indoor residual insecticide applications shift Aedes aegypti age structure and arbovirus transmission potential.Scientific reports · 2023Article
- Perspectives of vector management in the control and elimination of vector-borne zoonoses.Frontiers in microbiology · 2023Review
- Developing Wolbachia-based disease interventions for an extreme environment.PLoS pathogens · 2023Article
- Fitness costs of Wolbachia shift in locally-adapted Aedes aegypti mosquitoes.Environmental microbiology · 2022Article
- Genomic and Phenotypic Comparisons Reveal Distinct Variants ofApplied and environmental microbiology · 2022Article
- Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti.Parasites & vectors · 2022Article
- Extensive public health initiatives drive the elimination of Aedes aegypti (Diptera, Culicidae) from a town in regional Queensland: A case study from Gin Gin, Australia.PLoS neglected tropical diseases · 2022Article
- A decade of stability for wMel Wolbachia in natural Aedes aegypti populations.PLoS pathogens · 2022Article
- Control of sheep flystrike: what's been tried in the past and where to from here.Australian veterinary journal · 2022Review
- Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia.BMC genomics · 2021Article
- AApplied and environmental microbiology · 2021Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endosymbiotic bacteria Wolbachia pipientis (wMel strain) has been successfully established in several populations of Aedes aegypti, the primary dengue vector. The virulent Wolbachia strain wMelPop is known to cause several pathological impacts (increased egg mortality, life shortening, etc.) reducing overall fitness in the mosquito Ae. aegypti. Increased egg mortality could substantially reduce egg banks in areas with a lengthy monsoonal dry season, and be employed to eliminate local populations. We tested this application under semi-field cage conditions. First, we determined that wMelPop infection significantly reduced the survival of desiccation-resistant eggs of the dengue vector Ae. aegypti, with shade and temperature having a significant impact; nearly all wMelPop-infected eggs failed to hatch after 6 and 10 weeks in summer and winter conditions, respectively. In laboratory selection experiments we found that egg desiccation resistance can be increased by selection, and that this effect of wMelPop infection is due to the nuclear background of the host rather than Wolbachia. We then conducted an invasion of wMelPop within a semi-field cage using sustained weekly releases of wMelPop infected mosquitoes, with fixation achieved after 9 weeks. The egg populations wMelPop infected and an uninfected control were then subjected to a simulated prolonged monsoonal dry season (2.5 months) before flooding to induce hatching. The wMelPop infected eggs suffered significantly greater mortality than the controls, with only 0.67% and 4.35% of respective infected and uninfected eggs held in 99% shade hatching after 80 days. These studies suggest that wMelPop could be used to locally eliminate populations of Ae. aegypti that are exposed to prolonged dry conditions, particularly if combined with vector control.
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