Evidence map›Paper›PMID 26204264›Full record

ArticlePloS one2015

Spontaneous Activity Associated with Delusions of Schizophrenia in the Left Medial Superior Frontal Gyrus: A Resting-State fMRI Study.

Bin Gao, Yiquan Wang, Weibo Liu, Zhiyu Chen, Heshan Zhou, Jinyu Yang, Zachary Cohen, Yihong Zhu, Yufeng Zang

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Bin GaoDepartment of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
Yiquan WangHangzhou Seventh People's Hospital, Hangzhou, Zhejiang, PR China; Mental Health Center, School of Medicine, Zhe Jiang University, Hangzhou, Zhejiang, PR China.
Weibo LiuDepartment of Psychiatry, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
Zhiyu ChenHangzhou Seventh People's Hospital, Hangzhou, Zhejiang, PR China.
Heshan ZhouHangzhou First People's Hospital, Hangzhou, Zhejiang, PR China.
Jinyu YangDepartment of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.
Zachary CohenAlpert Medical School of Brown University, Richmond St., Providence, RI, United States of America.
Yihong ZhuDepartment of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China; Mental Health Education and Counseling Center, Zhejiang University, Hangzhou, Zhejiang, PR China.
Yufeng ZangCenter for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, Zhejiang, PR China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang, PR China.
Hangzhou Seventh Peoples Hospital · CNSecond Affiliated Hospital of Zhejiang University · CNZhejiang University · CNBrown University · USHangzhou First People's Hospital · CNHangzhou Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delusions of schizophrenia have been found to be associated with alterations of some brain regions in structure and task-induced activation. However, the relationship between spontaneously occurring symptoms and spontaneous brain activity remains unclear. In the current study, 14 schizophrenic patients with delusions and 14 healthy controls underwent a resting-state functional magnetic resonance imaging (RS-fMRI) scan. Patients with delusions of schizophrenia patients were rated with Positive and Negative Syndrome Scale (PANSS) and Characteristics of Delusional Rating Scale (CDRS). Regional homogeneity (ReHo) was calculated to measure the local synchronization of the spontaneous activity in a voxel-wise way. A two-sample t-test showed that ReHo of the right anterior cingulate gyrus and left medial superior frontal gyrus were higher in patients, and ReHo of the left superior occipital gyrus was lower, compared to healthy controls. Further, among patients, correlation analysis showed a significant difference between delusion scores of CRDS and ReHo of brain regions. ReHo of the left medial superior frontal gyrus was negatively correlated with patients' CDRS scores but not with delusional PANSS scores. These results suggested that altered local synchronization of spontaneous brain activity may be related to the pathophysiology of delusion in schizophrenia.

Indexed as

AdultBrain MappingDelusionsFemaleFrontal LobeFunctional LateralityHumansMagnetic Resonance ImagingMaleMiddle AgedSchizophreniaYoung Adult

Identifiers

PMID26204264
PMCPMC4512714
OpenAlexW2103990349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.