ArticlePloS one2015
Molecular Analysis of Antibiotic Resistance Determinants and Plasmids in Malaysian Isolates of Multidrug Resistant Klebsiella pneumoniae.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03767283 (Genetic Characterization of Plasmids Carrying Carbapenemases and Quinolone Resistance Determinants in Klebsiella Pneumoniae Isolates in Assiut University Hospitals), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Genetic Characterization of Plasmids Carrying Carbapenemases and Quinolone Resistance Determinants in Klebsiella Pneumoniae Isolates in Assiut University Hospitals
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology of multidrug-resistant Klebsiella pneumoniae infection in clinical setting in South-Eastern Asia: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2023Pooled it
- Genotypic and Phenotypic Detection of AmpC β-lactamases in Enterobacter spp. Isolated from a Teaching Hospital in Malaysia.PloS one · 2016Trial
- Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?BMC microbiology · 2025Article
- Phenotypic and Genotypic Profiles of Extended-Spectrum Beta-Lactamase-Producing Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Characterization of resistance genes and replicon typing in Carbapenem-resistant Klebsiella pneumoniae strains.Annals of clinical microbiology and antimicrobials · 2024Article
- Molecular Screening of Carbapenem-ResistantJournal of clinical medicine · 2023Article
- pKpQIL-like plasmid contributes to the dissemination ofIranian journal of microbiology · 2023Article
- Human pandemic K27-ST392 CTX-M-15 extended-spectrum β-lactamase-positiveOne health (Amsterdam, Netherlands) · 2022Article
- Prevalence and distribution of ampc beta-lactamase producingFrontiers in cellular and infection microbiology · 2022Article
- Article
- Genomic analysis revealing the resistance mechanisms of extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolated from pig and humans in Malaysia.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Genetic mechanisms and correlated risk factors of antimicrobial-resistant ESKAPEE pathogens isolated in a tertiary hospital in Malaysia.Antimicrobial resistance and infection control · 2021Article
- Molecular Characterization of Carbapenem ResistantPathogens (Basel, Switzerland) · 2021Article
- High throughput sequencing reveals the abundance and diversity of antibiotic-resistant bacteria in aquaculture wastewaters, Shandong, China.3 Biotech · 2021Article
- Observational
- Genetic characterization of ESBL-producing Escherichia coli and Klebsiella pneumoniae isolated from wastewater and river water in Tunisia: predominance of CTX-M-15 and high genetic diversity.Environmental science and pollution research international · 2020Article
- Pharmaceutical disposal facilitates the mobilization of resistance determinants among microbiota of polluted environment.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- The Inc FII Plasmid and its Contribution in the Transmission ofAntibiotics (Basel, Switzerland) · 2019Article
- Molecular Characterization of Carbapenem Resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae Isolated from Lebanon.Scientific reports · 2019Article
- Molecular detection and PCR-RFLP analysis usingJournal, genetic engineering & biotechnology · 2018Article
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3 authors.
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Abstract
Infections caused by multidrug resistant Klebsiella pneumoniae have been increasingly reported in many parts of the world. A total of 93 Malaysian multidrug resistant K. pneumoniae isolated from patients attending to University of Malaya Medical Center, Kuala Lumpur, Malaysia from 2010-2012 were investigated for antibiotic resistance determinants including extended-spectrum beta-lactamases (ESBLs), aminoglycoside and trimethoprim/sulfamethoxazole resistance genes and plasmid replicons. CTX-M-15 (91.3%) was the predominant ESBL gene detected in this study. aacC2 gene (67.7%) was the most common gene detected in aminoglycoside-resistant isolates. Trimethoprim/sulfamethoxazole resistance (90.3%) was attributed to the presence of sul1 (53.8%) and dfrA (59.1%) genes in the isolates. Multiple plasmid replicons (1-4) were detected in 95.7% of the isolates. FIIK was the dominant replicon detected together with 13 other types of plasmid replicons. Conjugative plasmids (1-3 plasmids of ~3-100 kb) were obtained from 27 of 43 K. pneumoniae isolates. An ESBL gene (either CTX-M-15, CTX-M-3 or SHV-12) was detected from each transconjugant. Co-detection with at least one of other antibiotic resistance determinants [sul1, dfrA, aacC2, aac(6')-Ib, aac(6')-Ib-cr and qnrB] was noted in most conjugative plasmids. The transconjugants were resistant to multiple antibiotics including β-lactams, gentamicin and cotrimoxazole, but not ciprofloxacin. This is the first study describing the characterization of plasmids circulating in Malaysian multidrug resistant K. pneumoniae isolates. The results of this study suggest the diffusion of highly diverse plasmids with multiple antibiotic resistance determinants among the Malaysian isolates. Effective infection control measures and antibiotic stewardship programs should be adopted to limit the spread of the multidrug resistant bacteria in healthcare settings.
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