Evidence map›Paper›PMID 26203461›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2015

Web-enabled Conversational Interactions as a Means to Improve Cognitive Functions: Results of a 6-Week Randomized Controlled Trial.

Hiroko H Dodge, Jian Zhu, Nora Mattek, Molly Bowman, Oscar Ybarra, Katherine Wild, David A Loewenstein, Jeffrey A Kaye

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01571427 (Conversational Engagement as a Means to Delay Alzheimer's Disease Onset), which is not on this map. Cited by 73 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 11 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01571427 early_phase1completednot on this map

Conversational Engagement as a Means to Delay Alzheimer's Disease Onset

TypeinterventionalSponsorOregon Health and Science UniversityRan2012 to 2013Enrolled83ConditionsMild Cognitive Impairment, Cognitive ChangeArmsActive social engagement group, Control group
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 11 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hiroko H DodgeDepartment of Neurology, NIA-Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, OR ; Oregon Center for Aging and Technology, Oregon Health & Science University, Portland, OR ; Department of Neurology, Michigan Alzheimer's Disease Center, University of Michigan Health System, Ann Arbor, MI.
Jian ZhuDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI.
Nora MattekDepartment of Neurology, NIA-Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, OR ; Oregon Center for Aging and Technology, Oregon Health & Science University, Portland, OR.
Molly BowmanDepartment of Neurology, NIA-Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, OR ; Oregon Center for Aging and Technology, Oregon Health & Science University, Portland, OR.
Oscar YbarraDepartment of Psychology, University of Michigan, Ann Arbor, MI.
Katherine WildDepartment of Neurology, NIA-Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, OR ; Oregon Center for Aging and Technology, Oregon Health & Science University, Portland, OR.
David A LoewensteinDepartment of Psychiatry & Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, Miami, FL.
Jeffrey A KayeDepartment of Neurology, NIA-Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, OR ; Oregon Center for Aging and Technology, Oregon Health & Science University, Portland, OR ; Portland VA Medical Center, Portland, OR.
Oregon Health & Science University · USUniversity of Michigan–Ann Arbor · USUniversity of Miami · US

Funding

Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI DODGE, HIROKO HAYAMA · 1990 to 2019
$27.7M
Pilot CoreP30AG024978 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2004 to 2023
$9.0M
Intelligent Systems for Detection of Aging ChangesR01AG024059 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2006 to 2010
$6.7M
Ambient Independence Measures for Guiding Care TransitionsR01AG042191 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2013 to 2017
$2.7M
Conversational Engagement as a Means to Delay Alzheimer's Disease OnsetR01AG033581 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI DODGE, HIROKO HAYAMA · 2010 to 2012
$1.5M
NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG024978NIA NIH HHS R01 AG024059NIA NIH HHS R01 AG033581NIA NIH HHS R01 AG042191
6 · The paper itself

Abstract

introductionIncreasing social interaction could be a promising intervention for improving cognitive function. We examined the feasibility of a randomized controlled trial to assess whether conversation-based cognitive stimulation, through personal computers, webcams, and a user-friendly interactive Internet interface had high adherence and a positive effect on cognitive functions among older adults without dementia.

methodsDaily 30 minute face-to-face communications were conducted over a 6-week trial period in the intervention group. The control group had only a weekly telephone interview. Cognitive status of normal and MCI subjects was operationally defined as Global Clinical Dementia Rating (CDR) = 0 and 0.5, respectively. Age, sex, education, Mini-Mental State Exam and CDR score were balancing factors in randomization. Subjects were recruited using mass-mailing invitations. Pre-post differences in cognitive test scores and loneliness scores were compared between control and intervention groups using linear regression models.

resultsEighty-three subjects participated (intervention: n=41, control: n=42). Their mean (std) age was 80.5 (6.8) years. Adherence to the protocol was high; there was no dropout and mean % of days completed out of the targeted trial days among the intervention group was 89% (range: 77%-100%). Among the cognitively intact participants, the intervention group improved more than the control group on a semantic fluency test (p=0.003) at the post-trial assessment and a phonemic fluency test (p=0.004) at the 18 DISCUSSION: Daily conversations via user-friendly Internet communication programs demonstrated high adherence. Among cognitively intact, the intervention group showed greater improvement in tests of language-based executive functions. Increasing daily social contacts through communication technologies could offer cost-effective home-based preventions. Further studies with a longer duration of follow-up are required to examine whether the intervention slows cognitive declines and delays the onset of dementia.

Indexed as

Communication TechnologyConversational InteractionInternetMild Cognitive Impairment (MCI)Oregon Center for Aging and Technology (ORCATECH)prevention studyRandomized controlled clinical trial (RCT)Social Engagement

Identifiers

PMID26203461
PMCPMC4507295
OpenAlexW1937723447

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.