Evidence map›Paper›PMID 26203459›Full record

ArticleSpirituality in clinical practice (Washington, D.C.)2015

The Role of Gratitude in Spiritual Well-being in Asymptomatic Heart Failure Patients.

Paul J Mills, Laura Redwine, Kathleen Wilson, Meredith A Pung, Kelly Chinh, Barry H Greenberg, Ottar Lunde, Alan Maisel, Ajit Raisinghani, Alex Wood and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Spirituality in clinical practice (Washington, D.C.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Can Gratitude Ease the Burden of Fibromyalgia? A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Religion/Spirituality and Prevalent Hypertension among Ethnic Cohorts in the Study on Stress, Spirituality, and Health.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
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  17. Article
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  19. Article
  20. Spirituality, Religious Attendance and Health Complaints in Czech Adolescents.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Paul J MillsDepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA ; Department of Psychiatry, University of California, San Diego, La Jolla, CA ; UC San Diego Center of Excellence for Research and Training in Global Integrative Health, University of California, San Diego, La Jolla, CA ; Chopra Center for Wellbeing, University of California, San Diego, La Jolla, CA.
Laura RedwineDepartment of Psychiatry, University of California, San Diego, La Jolla, CA ; UC San Diego Center of Excellence for Research and Training in Global Integrative Health, University of California, San Diego, La Jolla, CA.
Kathleen WilsonDepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA.
Meredith A PungDepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA.
Kelly ChinhDepartment of Psychiatry, University of California, San Diego, La Jolla, CA.
Barry H GreenbergDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Ottar LundeDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Alan MaiselDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Ajit RaisinghaniDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Alex WoodDepartment of Behavioral Science, University of Stirling, Stirling Scotland.
Deepak ChopraDepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA ; Chopra Center for Wellbeing, University of California, San Diego, La Jolla, CA.
University of California, San Diego · USUniversity of Stirling · GB

Funding

SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
BNP and Neuroimmune Characteristics of CHF &DepressionR01HL073355 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLS, PAUL J · 2005 to 2014
$5.6M
Exploring Tai Chi as a Behavioral Intervention for Heart Failure PatientsR01HL096784 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI REDWINE, LAURA S · 2010 to 2013
$1.5M
NCRR NIH HHS UL1 RR031980NHLBI NIH HHS R01 HL073355NHLBI NIH HHS R01 HL096784
6 · The paper itself

Abstract

Spirituality and gratitude are associated with wellbeing. Few if any studies have examined the role of gratitude in heart failure (HF) patients or whether it is a mechanism through which spirituality may exert its beneficial effects on physical and mental health in this clinical population. This study examined associations bet ween gratitude, spiritual wellbeing, sleep, mood, fatigue, cardiac-specific self-efficacy, and inflammation in 186 men and women with Stage B asymptomatic HF (age 66.5 years ±10). In correlational analysis, gratitude was associated with better sleep (r=-.25, p<0.01), less depressed mood (r=-.41, p<0.01), less fatigue (r=-.46, p<0.01), and better self-efficacy to maintain cardiac function (r=.42, p<0.01). Patients expressing more gratitude also had lower levels of inflammatory biomarkers (r=-.17, p<0.05). We further explored relationships among these variables by examining a putative pathway to determine whether spirituality exerts its beneficial effects through gratitude. We found that gratitude fully mediated the relationship between spiritual wellbeing and sleep quality (z=-2.35, SE=.03, p=.02) and also the relationship between spiritual wellbeing and depressed mood (z=-4.00, SE=.075, p<.001). Gratitude also partially mediated the relationships between spiritual wellbeing and fatigue (z=-3.85, SE=.18, p<.001), and between spiritual wellbeing and self-efficacy (z=2.91, SE=.04, p=.003). In sum, we report that gratitude and spiritual wellbeing are related to better mood and sleep, less fatigue, and more self-efficacy, and that gratitude fully or partially mediates the beneficial effects of spiritual wellbeing on these endpoints. Efforts to increase gratitude may be a treatment for improving wellbeing in HF patients' lives and be of potential clinical value.

Indexed as

gratitudeheart failureinflammationmoodsleepspiritual wellbeing

Identifiers

PMID26203459
PMCPMC4507265
OpenAlexW2135076712

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.