ArticleBiomedical optics express2015
Flux or speed? Examining speckle contrast imaging of vascular flows.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 88 citations in OpenAlex.
- Imaging photoplethysmography as an easy-to-use tool for monitoring changes in tissue blood perfusion during abdominal surgery.Scientific reports · 2022Trial
- Article
- Advanced optical phantom mimicking microvascular and directed blood flow in mouse brain.Biomedical engineering letters · 2026Article
- Multi-exposure speckle imaging through an optical fiber bundle.Journal of biomedical optics · 2025Article
- Minimally Invasive Bowel Cancer Detection through Vibrating Microrobot-Induced Elastography.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025Article
- Handheld laser speckle contrast imaging probe: quantitative video rate assessment of tissue perfusion in animal and patient applications.Biophotonics discovery · 2025Article
- Optimized laser speckle-based imaging system and methods for deep tissue cerebral blood flow imaging in small rodents.Neurophotonics · 2025Article
- Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease.Neurophotonics · 2025Article
- Wide-field intensity fluctuation imaging.Biomedical optics express · 2024Article
- Quantitative hemodynamic imaging: a method to correct the effects of optical properties on laser speckle imaging.Neurophotonics · 2023Article
- Design and validation of a convolutional neural network for fast, model-free blood flow imaging with multiple exposure speckle imaging.Biomedical optics express · 2023Article
- Wide-field Intensity Fluctuation Imaging.bioRxiv : the preprint server for biology · 2023Article
- Optical Flow-Based Full-Field Quantitative Blood-Flow Velocimetry Using Temporal Direction Filtering and Peak Interpolation.International journal of molecular sciences · 2023Article
- Prediction of motion artifacts caused by translation in handheld laser speckle contrast imaging.Journal of biomedical optics · 2023Article
- Speed-resolved perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning.Journal of biomedical optics · 2023Article
- All fiber-based illumination system for multi-exposure speckle imaging.Biomedical optics express · 2023Article
- Real-time tracking of brain oxygen gradients and blood flow during functional activation.Neurophotonics · 2022Article
- Continuous blood flow visualization with laser speckle contrast imaging during neurovascular surgery.Neurophotonics · 2022Article
- Dynamics of isoflurane-induced vasodilation and blood flow of cerebral vasculature revealed by multi-exposure speckle imaging.Journal of neuroscience methods · 2022Article
- Animal model of assessing cerebrovascular functional reserve by imaging photoplethysmography.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Speckle contrast imaging enables rapid mapping of relative blood flow distributions using camera detection of back-scattered laser light. However, speckle derived flow measures deviate from direct measurements of erythrocyte speeds by 47 ± 15% (n = 13 mice) in vessels of various calibers. Alternatively, deviations with estimates of volumetric flux are on average 91 ± 43%. We highlight and attempt to alleviate this discrepancy by accounting for the effects of multiple dynamic scattering with speckle imaging of microfluidic channels of varying sizes and then with red blood cell (RBC) tracking correlated speckle imaging of vascular flows in the cerebral cortex. By revisiting the governing dynamic light scattering models, we test the ability to predict the degree of multiple dynamic scattering across vessels in order to correct for the observed discrepancies between relative RBC speeds and multi-exposure speckle imaging estimates of inverse correlation times. The analysis reveals that traditional speckle contrast imagery of vascular flows is neither a measure of volumetric flux nor particle speed, but rather the product of speed and vessel diameter. The corrected speckle estimates of the relative RBC speeds have an average 10 ± 3% deviation in vivo with those obtained from RBC tracking.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.