ArticleBiomedical optics express2015
In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Live imaging of skin immunity using two-photon microscopy: a short review.Inflammation and regeneration · 2026Review
- Multi-Scale Label-Free Human Brain Imaging with Integrated Serial Sectioning Polarization Sensitive Optical Coherence Tomography and Two-Photon Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Observation and density estimation of a large number of skin capillaries using wide-field portable video capillaroscopy and semantic segmentation.Journal of biomedical optics · 2023Article
- Article
- In vivo optical molecular imaging of inflammation and immunity.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Analysis of skin morphological features and real-time monitoring using snapshot hyperspectral imaging.Biomedical optics express · 2019Article
- Three-photon tissue imaging using moxifloxacin.Scientific reports · 2018Article
- Visible continuum pulses based on enhanced dispersive wave generation for endogenous fluorescence imaging.Biomedical optics express · 2017Article
- Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo.Journal of neuroscience methods · 2016Article
- NO-dependent attenuation of TPA-induced immunoinflammatory skin changes in Balb/c mice by pindolol, heptaminol or ATRA, but not by verapamil.Oncotarget · 2016Article
- In vivo investigation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence tomography.Biomedical optics express · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation is a non-specific immune response to injury intended to protect biological tissue from harmful stimuli such as pathogens, irritants, and damaged cells. In vivo optical tissue imaging has been used to provide spatial and dynamic characteristics of inflammation within the tissue. In this paper, we report in vivo visualization of inflammation in the skin at both cellular and physiological levels by using a combination of label-free two-photon microscopy (TPM) and optical coherence tomography (OCT). Skin inflammation was induced by topically applying lipopolysaccharide (LPS) on the mouse ear. Temporal OCT imaging visualized tissue swelling, vasodilation, and increased capillary density 30 min and 1 hour after application. TPM imaging showed immune cell migration within the inflamed skin. Combined OCT and TPM was applied to obtain complementary information from each modality in the same region of interest. The information provided by each modality were consistent with previous reports about the characteristics of inflammation. Therefore, the combination of OCT and TPM holds potential for studying inflammation of the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.