Evidence map›Paper›PMID 26203367›Full record

ArticleBiomedical optics express2015

Characterization of structural-prior guided optical tomography using realistic breast models derived from dual-energy x-ray mammography.

Bin Deng, Dana H Brooks, David A Boas, Mats Lundqvist, Qianqian Fang

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Bin DengAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Dana H BrooksBSPIRAL group and ECE Dept., Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.
David A BoasAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Mats LundqvistPhilips Healthcare, Smidesvägen 5, 171 41 Solna, Sweden.
Qianqian FangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Athinoula A. Martinos Center for Biomedical Imaging · USNortheastern University · USPhilips (Sweden) · SE

Funding

3D Optical Imaging and Digital X-Ray of Breast LesionsR01CA097305 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2002 to 2013
$3.8M
Next-generation Monte Carlo eXtreme Light Transport Simulation PlatformR01GM114365 · NIGMS · NORTHEASTERN UNIVERSITY · PI FANG, QIANQIAN · 2015 to 2023
$2.9M
Integrated 3D Xray and Dynamic Tomographic Optical Breast Imaging SystemR01CA142575 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2010 to 2014
$2.7M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
NCI NIH HHS R01 CA097305NCI NIH HHS R01 CA142575NCRR NIH HHS S10 RR023043NIGMS NIH HHS R01 GM114365
6 · The paper itself

Abstract

Multi-spectral near-infrared diffuse optical tomography (DOT) is capable of providing functional tissue assessment that can complement structural mammographic images for more comprehensive breast cancer diagnosis. To take full advantage of the readily available sub-millimeter resolution structural information in a multi-modal imaging setting, an efficient x-ray/optical joint image reconstruction model has been proposed previously to utilize anatomical information from a mammogram as a structural prior. In this work, we develop a complex digital breast phantom (available at http://openjd.sf.net/digibreast) based on direct measurements of fibroglandular tissue volume fractions using dual-energy mammographic imaging of a human breast. We also extend our prior-guided reconstruction algorithm to facilitate the recovery of breast tumors, and perform a series of simulation-based studies to systematically evaluate the impact of lesion sizes and contrasts, tissue background, mesh resolution, inaccurate priors, and regularization parameters, on the recovery of breast tumors using multi-modal DOT/x-ray measurements. Our studies reveal that the optical property estimation error can be reduced by half by utilizing structural priors; the minimum detectable tumor size can also be reduced by half when prior knowledge regarding the tumor location is provided. Moreover, our algorithm is shown to be robust to false priors on tumor location.

Indexed as

(100.3190) Inverse problems(110.3080) Infrared imaging(170.3010) Image reconstruction techniques(170.3830) Mammography(200.4560) Optical data processing

Identifiers

PMID26203367
PMCPMC4505695
OpenAlexW2226432548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.