Evidence map›Paper›PMID 26203295›Full record

ArticleAdvances in genomics and genetics2015

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives.

Jennifer Zj Maccani, Matthew A Maccani

Abstract read
In one paragraph

Article in Advances in genomics and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2021
    Review
  17. Review
  18. Article
  19. Findings in Stillbirths Associated with Placental Disease.American journal of perinatology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jennifer Zj MaccaniPenn State Tobacco Center of Regulatory Science, College of Medicine, Department of Public Health Sciences, Hershey, PA, USA.
Matthew A MaccaniPenn State Tobacco Center of Regulatory Science, College of Medicine, Department of Public Health Sciences, Hershey, PA, USA.

Funding

Research Training and Educational Component (Component I) p370-385P50DA036107 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI FOULDS, JONATHAN, MUSCAT, JOSHUA E · 2013 to 2018
$19.5M
RESEARCH TRAINING IN CHILD MENTAL HEALTHT32MH019927 · NIMH · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI Kristen G Benito, Anthony Spirito · 1994 to 2026
$7.8M
Training in Behavioral & Preventive MedicineT32HL076134 · NHLBI · MIRIAM HOSPITAL · PI John Graham Thomas · 2006 to 2026
$5.7M
NHLBI NIH HHS T32 HL076134NIDA NIH HHS P50 DA036107NIMH NIH HHS T32 MH019927
6 · The paper itself

Abstract

The developmental origins of health and disease hypothesis states that adverse early life exposures can have lasting, detrimental effects on lifelong health. Exposure to maternal cigarette smoking during pregnancy is associated with morbidity and mortality in offspring, including increased risks for miscarriage, stillbirth, low birth weight, preterm birth, asthma, obesity, altered neurobehavior, and other conditions. Maternal cigarette smoking during pregnancy interferes with placental growth and functioning, and it has been proposed that this may occur through the disruption of normal and necessary placental epigenetic patterns. Epigenome-wide association studies have identified a number of differentially methylated placental genes that are associated with maternal smoking during pregnancy, including

Indexed as

epigeneticsplacentapregnancyprenataltobacco

Identifiers

PMID26203295
PMCPMC4507353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.