Evidence map›Paper›PMID 26203292›Full record

ArticleNature and science of sleep2015

Mild obstructive sleep apnea does not modulate baroreflex sensitivity in adult patients.

Henry Blomster, Tomi P Laitinen, Juha Ek Hartikainen, Tiina M Laitinen, Esko Vanninen, Helena Gylling, Johanna Sahlman, Jouko Kokkarinen, Jukka Randell, Juha Seppä and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature and science of sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Advancements in the neurocirculatory reflex response to hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Review
  3. Article
  4. Article
  5. ECG and Heart Rate Variability in Sleep-Related Breathing Disorders.Advances in experimental medicine and biology · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Henry BlomsterDepartment of Otorhinolaryngology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Tomi P LaitinenDepartment of Clinical Physiology and Nuclear Medicine, University of Eastern Finland, Kuopio, Finland.
Juha Ek HartikainenDepartment of Internal Medicine, University of Eastern Finland, Kuopio, Finland ; Heart Center, Kuopio University Hospital, Kuopio, Finland.
Tiina M LaitinenDepartment of Clinical Physiology and Nuclear Medicine, University of Eastern Finland, Kuopio, Finland.
Esko VanninenDepartment of Clinical Physiology and Nuclear Medicine, University of Eastern Finland, Kuopio, Finland.
Helena GyllingDepartment of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland ; Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland.
Johanna SahlmanDepartment of Otorhinolaryngology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Jouko KokkarinenDepartment of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland.
Jukka RandellDepartment of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland.
Juha SeppäDepartment of Otorhinolaryngology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Henri TuomilehtoDepartment of Clinical Nutrition, School of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland ; Oivauni Sleep Clinic, Kuopio, Finland.
University of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnea (OSA) is a chronic and progressive disease. OSA is associated with increased cardiovascular morbidity and mortality, the risk being more frequently encountered with severe degrees of OSA. Increased sympathetic activation and impaired cardiac autonomic control as reflected by depressed baroreceptor reflex sensitivity (BRS) are possible mechanisms involved in the cardiovascular complications of OSA. However, it is not known at what stage of OSA that changes in BRS appear. The aim of this study was to evaluate BRS in patients with mild OSA.

methodsThe study population consisted of 81 overweight patients with mild OSA and 46 body weight-matched non-OSA subjects. BRS, apnea-hypopnea index, body mass index, and metabolic parameters were assessed. The phenylephrine test was used to measure BRS.

resultsPatients in the OSA group were slightly but significantly older than the non-OSA population (50.3±9.3 years vs 45.7±11.1 years, P=0.02). Body mass index, percentage body fat, blood pressure, fasting glucose, insulin, and lipid levels did not differ between the OSA patients and non-OSA subjects. Absolute BRS values in patients with mild OSA and non-OSA subjects (9.97±6.70 ms/mmHg vs 10.51±7.16 ms/mmHg, P=0.67) and BRS values proportional to age-related and sex-related reference values (91.4%±22.7% vs 92.2%±21.8%, P=0.84) did not differ from each other. BRS <50% of the sex-specific reference value was found in 6% of patients with mild OSA and in 2% of non-OSA subjects (P=0.29).

conclusionPatients with mild OSA did not show evidence of disturbed BRS in comparison with weight-matched non-OSA controls.

Indexed as

baroreceptor reflex sensitivityobstructive sleep apnea

Identifiers

PMID26203292
PMCPMC4487157
OpenAlexW1923521744

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.