ArticleBreast cancer (Dove Medical Press)2015
Identification of genes involved in breast cancer and breast cancer stem cells.
Article in Breast cancer (Dove Medical Press), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
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- Multi-omic underpinnings of epigenetic aging and human longevity.Nature communications · 2023Article
- Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression.BMC genomic data · 2022Article
- A Novel Inflammatory Response-Related Gene Signature Predicts Immune Status and Prognosis of Breast Cancer.Journal of oncology · 2022Article
- Synthesis and characterization of a novel pH-responsive drug-releasing nanocomposite hydrogel for skin cancer therapy and wound healing.Journal of materials chemistry. B · 2021Article
- Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Review
- Novel antibody against TMX2 and its effects on breast cancer cells.International journal of biochemistry and molecular biology · 2020Article
- DDX49 is a novel biomarker and therapeutic target for lung cancer metastases.Journal of cellular and molecular medicine · 2020Article
- DDX49 is an RNA helicase that affects translation by regulating mRNA export and the levels of pre-ribosomal RNA.Nucleic acids research · 2018Article
- Expression of embryonal stem cell transcription factors in breast cancer: Oct4 as an indicator for poor clinical outcome and tamoxifen resistance.Oncotarget · 2017Article
- Salinomycin reduces stemness and induces apoptosis on human ovarian cancer stem cell.Journal of gynecologic oncology · 2017Article
- Clinical implications of the coexpression of SRC1 and NANOG in HER-2-overexpressing breast cancers.OncoTargets and therapy · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is the most frequent type of cancer in women. Great progress has been made in its treatment but relapse is common. One hypothesis to account for the high recurrence rates is the presence of cancer stem cells (CSCs), which have the ability to self-renew and differentiate into multiple malignant cell types. This study aimed to determine genes that are expressed in breast cancer and breast CSCs and to investigate their correlation with stemness. RNA was extracted from established breast cancer cell lines and from CSCs derived from five different breast cancer patients. DNA microarray analysis was performed and any upregulated genes were also studied in other cancer types, including colorectal and lung cancer. For genes that were expressed only in breast cancer, knockdown-based experiments were performed. Finally, the gene expression levels of stemness transcription factors were measured. The outcome of the analysis indicated a group of genes that were aberrantly expressed mainly in breast cancer cells with stemness properties. Knockdown experiments confirmed the impact of several of these on NANOG, OCT3/4, and SOX2 transcription factors. It seems that several genes that are not directly related with hormone metabolism and basic signal transduction pathways might have an important role in relapse and disease progression and, thus, can be targeted for new treatment approaches for breast cancer.
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