Evidence map›Paper›PMID 26203218›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2015

Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis.

José-Juan Mondejar, David Salom, Salvador Garcia-Delpech, Manuel Diaz-Llopis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

José-Juan MondejarOphthalmology Department, School of Medicine, University of Valencia, Valencia, Spain ; Ophthalmology Department, Hospital General Universitario de Alicante, Alicante, Spain.
David SalomOphthalmology Department, School of Medicine, University of Valencia, Valencia, Spain ; Ophthalmology Department, Hospital de Manises, Valencia, Spain.
Salvador Garcia-DelpechOphthalmology Department, School of Medicine, University of Valencia, Valencia, Spain ; Ophthalmology Department, Hospital Universitario La Fe, Valencia, Spain.
Manuel Diaz-LlopisOphthalmology Department, School of Medicine, University of Valencia, Valencia, Spain.
Hospital de Manises · ESHospital General Universitario de Alicante Doctor Balmis · ESHospital Universitari i Politècnic La Fe · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo measure thrombopoietin (TPO) levels in the serum and aqueous humors of patients with noninfectious acute anterior uveitis.

methodsA prospective, comparative, controlled study. Serum and aqueous humors were obtained from the eyes of 16 patients with noninfectious acute anterior uveitis. TPO levels were measured using an enzyme-linked immunosorbent assay (ELISA). The results obtained were compared with those of a control group.

resultsSerum concentrations of TPO were not significantly different between control individuals and patients with active anterior uveitis. Aqueous humor TPO levels were 54.46±16.24 pg/mL in the eyes of patients with uveitis, and 34.32±11.63 pg/mL in the eyes of controls. The difference between the two groups was significant (Mann-Whitney U-test for independent data, P=0.0008), with uveitis patients exhibiting significantly higher levels of TPO.

conclusionThe high levels of TPO in the aqueous humors of uveitis patients points toward a cytoprotective role of this factor in inflammatory repair processes and the recovery of tissue homeostasis.

Indexed as

acute anterior uveitisaqueous humorscytoprotectiveserumthrombopoietinTPO

Identifiers

PMID26203218
PMCPMC4508089
OpenAlexW1883349841

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.