ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Parasite Antigen-Specific Regulation of Th1, Th2, and Th17 Responses in Strongyloides stercoralis Infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Helminth Coinfection Alters Monocyte Activation, Polarization, and Function in LatentJournal of immunology (Baltimore, Md. : 1950) · 2020Trial
- Helminths in alternative therapeutics of inflammatory bowel disease.Intestinal research · 2025Review
- Lifestyle score is associated with cellular immune profiles in healthy Tanzanian adults.Brain, behavior, & immunity - health · 2024Article
- Progresses and challenges inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
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- Regulation of piglet T-cell immune responses by thioredoxin peroxidase fromFrontiers in microbiology · 2022Article
- Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.PLoS neglected tropical diseases · 2021Article
- Systemic profile of immune factors in an elderly Italian population affected by chronic strongyloidiasis.Parasites & vectors · 2020Article
- Co-infection with Strongyloides stercoralis hyperinfection syndrome and Klebsiella in a nephrotic syndrome patient: A case report.Medicine · 2019Article
- Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4)- and Programmed Death 1 (PD-1)-Mediated Regulation of Monofunctional and Dual Functional CD4Infection and immunity · 2019Article
- Review
- Altered levels of memory T cell subsets and common γc cytokines in Strongyloides stercoralis infection and partial reversal following anthelmintic treatment.PLoS neglected tropical diseases · 2018Article
- Elevated Systemic and Parasite-Antigen Stimulated Levels of Type III IFNs in a Chronic Helminth Infection and Reversal Following Anthelmintic Treatment.Frontiers in immunology · 2018Article
- Molecular and Cellular Response to ExperimentalFrontiers in immunology · 2018Article
- Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes.Parasites & vectors · 2017Article
- Modulation of CD4Infection and immunity · 2017Article
- Helminths as an alternative therapy for intestinal diseases.World journal of gastroenterology · 2017Article
- Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania.PLoS neglected tropical diseases · 2017Article
- Human infection with Strongyloides stercoralis and other related Strongyloides species.Parasitology · 2017Review
- Peripheral blood CD4Parasitology research · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Chronic helminth infections are known to be associated with modulation of Ag-specific CD4(+) T responses. However, the role of CD4(+) T cell responses in human infection with Strongyloides stercoralis is not well defined. To examine the role of CD4(+) T cells expressing Th1, Th2, and Th17 cytokines in strongyloidiasis, we compared the frequency (Fo) of these subsets in infected (INF) individuals with Fo in S. stercoralis-uninfected (UN) individuals. INF individuals exhibited a significant decrease in the spontaneous and Ag-specific Fo of both monofunctional and dual-functional Th1 cells compared with UN. Similarly, INF individuals also exhibited significantly decreased Fo of monofunctional and dual-functional Th17 cells upon Ag stimulation compared with UN. In contrast, both the spontaneous and the Ag-induced Fo of monofunctional and dual-functional Th2 cells was significantly increased in INF compared with UN individuals. This differential T cell response was predominantly Ag specific because it was abrogated upon control Ag or mitogen stimulation. The regulation of Th1, Th2, and Th17 cells was predominantly dependent on IL-10, whereas the regulation of Th2, but not Th1 or Th17, cells was also dependent on TGF-β. In addition, treatment of S. stercoralis infection significantly increased the Ag-specific Fo of Th1 and Th17 cells and decreased the Fo of Th2 cells in INF individuals. Thus, S. stercoralis infection is characterized by a parasite Ag-dependent regulation of monofunctional and dual-functional Th1, Th2, and Th17 cells, a regulation also reversible by antihelminthic treatment.
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