SynthesisAdvances in therapy2015
Critical Appraisal on Orbital Decompression for Thyroid Eye Disease: A Systematic Review and Literature Search.
Synthesis in Advances in therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Deep lateral orbital decompression for Graves orbitopathy: a systematic review.International ophthalmology · 2021Pooled it
- Tocilizumab for thyroid eye disease.The Cochrane database of systematic reviews · 2018Pooled it
- Reduced haemorrhage during external medial orbital wall decompression with nasal packing containing vasoconstrictive agent.BMJ open ophthalmology · 2026Trial
- Rehabilitative orbital decompression for Graves' orbitopathy: results of a randomized clinical trial.Journal of endocrinological investigation · 2018Trial
- Approach to the patient: therapeutic mitigation of lacrimal manifestations in thyroid eye disease.The Journal of clinical endocrinology and metabolism · 2026Review
- Computational Simulation of LAVA Treatment of Thyroid Eye Disease Predicts Soft Tissue Outcome Comparable to Two-Wall Resection.Bioengineering (Basel, Switzerland) · 2024Article
- Thyroid Eye Disease.Life (Basel, Switzerland) · 2022Review
- Consideration of specific key points improves outcome of decompression treatment in patients with endocrine orbitopathy: pre-/post-OP comparison and biomechanical simulation.European journal of medical research · 2022Article
- Advances in the Treatment of Thyroid Eye Disease Associated Extraocular Muscle Myopathy and Optic Neuropathy.Current neurology and neuroscience reports · 2022Review
- Update on the surgical management of Graves' orbitopathy.Frontiers in endocrinology · 2022Review
- A data-driven approach for the discovery of biomarkers associated with thyroid eye disease.BMC ophthalmology · 2021Article
- Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid-associated ophthalmopathy.Experimental and therapeutic medicine · 2020Article
- Three-dimensional characterisation of the globe position in the orbit.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Development of a core outcome set for amblyopia, strabismus and ocular motility disorders: a review to identify outcome measures.BMC ophthalmology · 2019Review
- Challenges in Orphan Drug Development: Identification of Effective Therapy for Thyroid-Associated Ophthalmopathy.Annual review of pharmacology and toxicology · 2019Review
- Cutting-edge endonasal surgical approaches to thyroid ophthalmopathy.Laryngoscope investigative otolaryngology · 2018Review
- Extraocular muscle repositioning as the last therapeutic option for a patient with a severe course of Graves' Ophthalmopathy: a case report.BMC ophthalmology · 2018Article
- Orbital decompression surgery for the treatment of Graves' ophthalmopathy: comparison of different techniques and long-term results.International journal of ophthalmology · 2018Article
- Article
- Orbital Decompression for Thyroid Eye Disease.Seminars in plastic surgery · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOrbital decompression is the indicated procedure for addressing exophthalmos and compressive optic neuropathy in thyroid eye disease. There are an abundance of techniques for removal of orbital bone, fat, or a combination published in the scientific literature. The relative efficacy and complications of these interventions in relation to the specific indications remain as yet undocumented. We performed a systematic review of the current published evidence for the effectiveness of orbital decompression, possible complications, and impact on quality of life.
methodsWe searched the current databases for medical literature and controlled trials, oculoplastic textbooks, and conference proceedings to identify relevant data up to February 2015. We included randomized controlled trials (RCTs) comparing two or more interventions for orbital decompression.
resultsWe identified only two eligible RCTs for inclusion in the review. As a result of the significant variability between studies on decompression, i.e., methodology and outcome measures, we did not perform a meta-analysis. One study suggests that the transantral approach and endonasal technique had similar effects in reducing exophthalmos but the latter is safer. The second study provides evidence that intravenous steroids may be superior to primary surgical decompression in the management of compressive optic neuropathy requiring less secondary surgical procedures.
conclusionMost of the published literature on orbital decompression consists of retrospective, uncontrolled trials. There is evidence from those studies that removal of the medial and lateral wall (balanced) and the deep lateral wall decompression, with or without fat removal, may be the most effective surgical methods with only few complications. There is a clear unmet need for controlled trials evaluating the different techniques for orbital decompression. Ideally, future studies should address the effectiveness, possible complications, quality of life, and cost of each intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.