Evidence map›Paper›PMID 26202824›Full record

ArticleBMC bioinformatics2015

Semi-supervised Learning for the BioNLP Gene Regulation Network.

Thomas Provoost, Marie-Francine Moens

Abstract read
In one paragraph

Article in BMC bioinformatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thomas Provoost
Marie-Francine Moens

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe BioNLP Gene Regulation Task has attracted a diverse collection of submissions showcasing state-of-the-art systems. However, a principal challenge remains in obtaining a significant amount of recall. We argue that this is an important quality for Information Extraction tasks in this field. We propose a semi-supervised framework, leveraging a large corpus of unannotated data available to us. In this framework, the annotated data is used to find plausible candidates for positive data points, which are included in the machine learning process. As this is a method principally designed for gaining recall, we further explore additional methods to improve precision on top of this. These are: weighted regularisation in the SVM framework, and filtering out unlabelled examples based on a probabilistic rule-finding method. The latter method also allows us to add candidates for negatives from unlabelled data, a method not viable in the unfiltered approach.

resultsWe replicate one of the original participant systems, and modify it to incorporate our methods. This allows us to test the extent of our proposed methods by applying them to the GRN task data. We find a considerable improvement in recall compared to the baseline system. We also investigate the evaluation metrics and find several mechanisms explaining a bias towards precision. Furthermore, these findings uncover an intricate precision-recall interaction, depriving recall of its habitual immediacy seen in traditional machine learning set-ups.

conclusionOur contributions are twofold.

Indexed as

Gene Regulatory NetworksGenesInformation Storage and RetrievalSupervised Machine LearningComputational BiologyData MiningHumans

Identifiers

PMID26202824
PMCPMC4511406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.