ArticleScientific reports2015
Identification of Drosophila Mutants Affecting Defense to an Entomopathogenic Fungus.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- The modern expansion of Dscam1 isoform diversity in Drosophila is linked to fitness and immunity.PLoS biology · 2025Article
- Latitudinal Clines in Climate and Sleep Patterns Shape Disease Outcomes inEcology and evolution · 2025Article
- An unusual Toll/MyD88-mediatedFly · 2024Article
- Metarhizium fight club: Within-host competitive exclusion and resource partitioning.PLoS pathogens · 2024Article
- A New Overview of Sex Bias in Fungal Infections.Journal of fungi (Basel, Switzerland) · 2024Review
- Effects of an entomopathogenic fungus on the reproductive potential ofEcology and evolution · 2024Article
- Opportunities for optimizing fungal biological control agents for long-term and effective management of insect pests of orchards and vineyards: a review.Frontiers in fungal biology · 2024Review
- AVirulence · 2023Article
- Genetic variation in disease resistance in Drosophila spp. is mitigated in Drosophila sechellia by specialization to a toxic host.Scientific reports · 2023Article
- A life-and-death struggle: interaction of insects with entomopathogenic fungi across various infection stages.Frontiers in immunology · 2023Review
- Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7.Cell host & microbe · 2021Article
- Microbial Response to Fungal Infection in a Fungus-Growing Termite,Frontiers in microbiology · 2021Article
- Review
- Fruit host-dependent fungal communities in the microbiome of wild Queensland fruit fly larvae.Scientific reports · 2020Article
- Genetic variation for resistance to the specific fly pathogen Entomophthora muscae.Scientific reports · 2020Article
- Microbiome of the Queensland Fruit Fly through Metamorphosis.Microorganisms · 2020Article
- Sexual Dimorphisms in Innate Immunity and Responses to Infection inFrontiers in immunology · 2019Review
- Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia.PLoS genetics · 2018Article
- Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps.BMC biology · 2017Article
- Fine scale mapping of genomic introgressions within the Drosophila yakuba clade.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungi cause the majority of insect disease. However, to date attempts to model host-fungal interactions with Drosophila have focused on opportunistic human pathogens. Here, we performed a screen of 2,613 mutant Drosophila lines to identify host genes affecting susceptibility to the natural insect pathogen Metarhizium anisopliae (Ma549). Overall, 241 (9.22%) mutant lines had altered resistance to Ma549. Life spans ranged from 3.0 to 6.2 days, with females being more susceptible than males in all lines. Speed of kill correlated with within-host growth and onset of sporulation, but total spore production is decoupled from host genotypes. Results showed that mutations affected the ability of Drosophila to restrain rather than tolerate infections and suggested trade-offs between antifungal and antibacterial genes affecting cuticle and gut structural barriers. Approximately, 13% of mutations where in genes previously associated with host pathogen interactions. These encoded fast-acting immune responses including coagulation, phagocytosis, encapsulation and melanization but not the slow-response induction of anti-fungal peptides. The non-immune genes impact a wide variety of biological functions, including behavioral traits. Many have human orthologs already implicated in human disorders; while others were mutations in protein and non-protein coding genes for which disease resistance was the first biological annotation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.