ArticleHepatology international2014
Diastolic cardiac dysfunction is a predictor of dismal prognosis in patients with liver cirrhosis.
Article in Hepatology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Liver cirrhosis and left ventricle diastolic dysfunction: Systematic review.World journal of gastroenterology · 2019Pooled it
- Clinical significance of resting and dobutamine stress myocardial work in cirrhotic cardiomyopathy.Echo research and practice · 2026Article
- Age-Stratified Mortality Outcomes Associated with Nonselective Beta-Blocker Use in Patients with Decompensated Cirrhosis.Journal of clinical medicine · 2026Article
- Cirrhotic cardiomyopathy in children with biliary atresia and genetic intrahepatic cholestasis: clinical course and outcomes.Hepatology international · 2026Observational
- B-Blockers in Liver Cirrhosis: A Wonder Drug for Every Stage of Portal Hypertension? A Narrative Review.Biomedicines · 2023Review
- How non-alcoholic fatty liver disease and cirrhosis affect the heart.Hepatology international · 2023Review
- Corrected QT interval in cirrhosis: A systematic review and meta-analysis.World journal of hepatology · 2023Article
- Value of red blood cell distribution width in prediction of diastolic dysfunction in cirrhotic cardiomyopathy.World journal of gastroenterology · 2023Article
- What's New in Cirrhotic Cardiomyopathy?-Review Article.Journal of personalized medicine · 2021Review
- Impact of left ventricular diastolic dysfunction on liver transplantation outcomes based on the latest American Society of Echocardiography/European Association of Cardiovascular Imaging recommendations.Clinical and experimental hepatology · 2021Article
- Diastolic Dysfunction Is a Predictor of Poor Survival in Patients with Decompensated Cirrhosis.International journal of hepatology · 2021Article
- B-type peptides to predict post-liver transplant mortality: systematic review and meta-analysis.Canadian liver journal · 2019Review
- Article
- Cardiac diastolic dysfunction predicts poor prognosis in patients with decompensated liver cirrhosis.Clinical and molecular hepatology · 2018Article
- Article
- Diastolic dysfunction in cirrhosis.Heart failure reviews · 2016Review
- Cirrhotic cardiomyopathy.World journal of gastroenterology · 2015Review
- Recent advances in cirrhotic cardiomyopathy.Digestive diseases and sciences · 2015Review
- Cirrhotic cardiomyopathy: Implications for the perioperative management of liver transplant patients.World journal of hepatology · 2015Review
- Assessment of diastolic function in the management of patients with cirrhosis.Hepatology international · 2014Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeLeft ventricular diastolic dysfunction (LVDD) constitutes the prominent characteristic of cirrhotic cardiomyopathy, but its relevance on the clinical course of cirrhotic patients has not been clearly defined. The aim of the study was to evaluate the relationship of LVDD with the severity and etiology of liver disease and to investigate whether it affects the outcome of cirrhotic patients.
methodsCardiac function of 45 cirrhotics was studied by a tissue Doppler imaging echocardiography. Diagnosis of LVDD was made according to the latest guidelines of the American Society of Echocardiography. All patients were followed up for a period of 2 years. Death or liver transplantation was the endpoint of the study.
resultsLVDD was found in 17 (38 %) of 45 patients. Its presence was not found to be associated with the etiology and stage of cirrhosis, but its severity was directly correlated with the Child-Pugh score. At the end of follow-up, 14 patients had died; 9 had LVDD (9/17, 53 %) and 5 had not (5/28, 18 %). Patients who died at the beginning of observation period had a higher Child-Pugh and MELD score, higher BNP, lower albumin and more prolonged QTc. On Kaplan-Meier analysis, patients with LVDD had statistically significantly worse prognosis compared to those without (p = 0.013, log rank: 5.495). Low albumin values (p = 0.003) and presence of LVDD (p = 0.017) were independent predictive factors of mortality.
conclusionsLVDD is a common complication of cirrhosis. As its development seems to be related to a worse prognosis, patients with LVDD must be under a strict follow-up.
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