ArticleJournal of the Royal Society, Interface2015
Global relationships in fluctuation and response in adaptive evolution.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- From Energy Deprivation Stress to Catalytic Adaptation of Reductive Dehalogenase TmrA for 1,1-DCA Dechlorination: An Experimental and in Silico Study.Microbial biotechnology · 2026Article
- Conserved wing shape variation across biological scales unveils dialectical relationships between micro- and macroevolution.Communications biology · 2025Article
- Dimensional reduction and adaptation-development-evolution relation in evolved biological systems.Biophysical reviews · 2024Review
- Developmental noise and phenotypic plasticity are correlated inEvolution letters · 2024Article
- Utilizing developmental dynamics for evolutionary prediction and control.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Biodiversity and Constrained Information Dynamics in Ecosystems: A Framework for Living Systems.Entropy (Basel, Switzerland) · 2023Article
- The Boltzmann distributions of molecular structures predict likely changes through random mutations.Biophysical journal · 2023Article
- Canalisation and plasticity on the developmental manifold of Caenorhabditis elegans.Molecular systems biology · 2023Article
- Experimental evidence for the correlation between RNA structural fluctuations and the frequency of beneficial mutations.RNA (New York, N.Y.) · 2022Article
- Heterosis of fitness and phenotypic variance in the evolution of a diploid gene regulatory network.PNAS nexus · 2022Article
- Toward understanding of evolutionary constraints: experimental and theoretical approaches.Biophysical reviews · 2020Review
- Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro.Nature communications · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells change their internal state to adapt to environmental changes, and evolve in response to the new conditions. The phenotype changes first via adaptation in response to environmental changes, and then through mutational changes in the genomic sequence, followed by selection in evolution. Here, we analysed simulated adaptive evolution using a simple cell model consisting of thousands of intracellular components, and found that the changes in their concentrations by adaptation are proportional to those by evolution across all the components, where the proportion coefficient between the two agreed well with the change in the growth rate of a cell. Furthermore, we demonstrate that the phenotypic variance in concentrations of cellular components due to (non-genetic) noise and to genomic alternations is proportional across all components. This implies that the specific phenotypes that are highly evolvable were already given by non-genetic fluctuations. These global relationships in cellular states were also supported by phenomenological theory based on steady reproduction and transcriptome analysis of laboratory evolution in Escherichia coli. These findings demonstrate that a possible evolutionary change in phenotypic state is highly restricted. Our results provide a basis for the development of a quantitative theory of plasticity and robustness in phenotypic evolution.
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