Evidence map›Paper›PMID 26202612›Full record

ReviewPsychopharmacology2015

The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia.

M Hvoslef-Eide, A C Mar, S R O Nilsson, J Alsiö, C J Heath, L M Saksida, T W Robbins, T J Bussey

Abstract readReview
PubMed Publisher
In one paragraph

Review in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Effects of psilocybin, the 5-HTPsychopharmacology · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Inhibition of Catechol-Frontiers in behavioral neuroscience · 2020
    Article
  18. Article
  19. Article
  20. An Overview of Animal Models Related to Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M Hvoslef-EideDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK. mh473@cam.ac.uk.
A C MarDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
S R O NilssonDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
J AlsiöDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
C J HeathDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
L M SaksidaDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
T W RobbinsDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
T J BusseyDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleThe NEWMEDS initiative (Novel Methods leading to New Medications in Depression and Schizophrenia, http://www.newmeds-europe.com ) is a large industrial-academic collaborative project aimed at developing new methods for drug discovery for schizophrenia. As part of this project, Work package 2 (WP02) has developed and validated a comprehensive battery of novel touchscreen tasks for rats and mice for assessing cognitive domains relevant to schizophrenia.

objectivesThis article provides a review of the touchscreen battery of tasks for rats and mice for assessing cognitive domains relevant to schizophrenia and highlights validation data presented in several primary articles in this issue and elsewhere.

methodsThe battery consists of the five-choice serial reaction time task and a novel rodent continuous performance task for measuring attention, a three-stimulus visual reversal and the serial visual reversal task for measuring cognitive flexibility, novel non-matching to sample-based tasks for measuring spatial working memory and paired-associates learning for measuring long-term memory.

resultsThe rodent (i.e. both rats and mice) touchscreen operant chamber and battery has high translational value across species due to its emphasis on construct as well as face validity. In addition, it offers cognitive profiling of models of diseases with cognitive symptoms (not limited to schizophrenia) through a battery approach, whereby multiple cognitive constructs can be measured using the same apparatus, enabling comparisons of performance across tasks.

conclusionThis battery of tests constitutes an extensive tool package for both model characterisation and pre-clinical drug discovery.

Indexed as

Schizophrenic PsychologyAnimalsAntipsychotic AgentsCognitionCognition DisordersConditioning, OperantMicePsychomotor PerformanceRatsSchizophreniaAntipsychotic AgentsAttentionCognitive flexibilityDrug discoveryExecutive functionLong-term memoryMouseNeuropsychiatric diseaseRatResponse inhibitionWorking memory

Identifiers

PMID26202612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.