ArticleMolecular biology of the cell2015
The EHD protein Past1 controls postsynaptic membrane elaboration and synaptic function.
Article in Molecular biology of the cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies.Traffic (Copenhagen, Denmark) · 2026Review
- Distinct input-specific mechanisms enable presynaptic homeostatic plasticity.Science advances · 2025Article
- Distinct input-specific mechanisms enable presynaptic homeostatic plasticity.bioRxiv : the preprint server for biology · 2024Article
- Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm.Cellular and molecular life sciences : CMLS · 2024Article
- PACSIN proteins in vivo: Roles in development and physiology.Acta physiologica (Oxford, England) · 2022Review
- The calcineurin regulator Sarah enables distinct forms of homeostatic plasticity at theFrontiers in synaptic neuroscience · 2022Article
- Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals.The Journal of cell biology · 2021Article
- Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction.Cellular and molecular life sciences : CMLS · 2021Review
- An early endosome-derived retrograde trafficking pathway promotes secretory granule maturation.The Journal of cell biology · 2020Article
- Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling.Nature communications · 2019Article
- Article
- Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation.eLife · 2018Article
- Disparate Postsynaptic Induction Mechanisms Ultimately Converge to Drive the Retrograde Enhancement of Presynaptic Efficacy.Cell reports · 2017Article
- Past1 Modulates Drosophila Eye Development.PloS one · 2017Article
- Filamin, a synaptic organizer ineLife · 2016Article
- Syndapin/SDPN-1 is required for endocytic recycling and endosomal actin association in the C. elegans intestine.Molecular biology of the cell · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Membranes form elaborate structures that are highly tailored to their specialized cellular functions, yet the mechanisms by which these structures are shaped remain poorly understood. Here, we show that the conserved membrane-remodeling C-terminal Eps15 Homology Domain (EHD) protein Past1 is required for the normal assembly of the subsynaptic muscle membrane reticulum (SSR) at the Drosophila melanogaster larval neuromuscular junction (NMJ). past1 mutants exhibit altered NMJ morphology, decreased synaptic transmission, reduced glutamate receptor levels, and a deficit in synaptic homeostasis. The membrane-remodeling proteins Amphiphysin and Syndapin colocalize with Past1 in distinct SSR subdomains and collapse into Amphiphysin-dependent membrane nodules in the SSR of past1 mutants. Our results suggest a mechanism by which the coordinated actions of multiple lipid-binding proteins lead to the elaboration of increasing layers of the SSR and uncover new roles for an EHD protein at synapses.
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