ArticleMolecular plant pathology2016
High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- SRF3 couples cellular iron homeostasis and defense responses through ubiquitin-dependent nano-organization.Science advances · 2026Article
- Bioengineering microbial cellulose synthesis pathways as biofactory for industrial-scale cellulose production: a review on current advances.World journal of microbiology & biotechnology · 2026Review
- Cyclic-di-GMP controls Type III effector export and symptom development in Pseudomonas syringae infections via the export ATPase HrcN.PLoS pathogens · 2025Article
- Comparative Transcriptomics and Metabolomics Uncover the Molecular Basis of Leaf Rust Resistance in ContrastingInternational journal of molecular sciences · 2025Article
- Plant Pattern recognition receptors: Exploring their evolution, diversification, and spatiotemporal regulation.Current opinion in plant biology · 2024Article
- Multiple Chitin- or Avirulent Strain-Triggered Immunity Induces Microbiome Reassembly in Rice.Microorganisms · 2024Article
- The plant endomicrobiome: Structure and strategies to produce stress resilient future crop.Current research in microbial sciences · 2024Review
- Co-evolution within the plant holobiont drives host performance.EMBO reports · 2023Review
- Cyclic di-GMP Signaling Links Biofilm Formation and Mn(II) Oxidation in Pseudomonas resinovorans.mBio · 2022Article
- Extracytoplasmic sigma factor AlgU contributes to fitness of Pseudomonas aeruginosa PGPR2 during corn root colonization.Molecular genetics and genomics : MGG · 2022Article
- Pseudomonas syringae addresses distinct environmental challenges during plant infection through the coordinated deployment of polysaccharides.Journal of experimental botany · 2022Article
- The right microbe-associated molecular patterns for effective recognition by plants.Frontiers in microbiology · 2022Review
- Yin and Yang of Biofilm Formation and Cyclic di-GMP Signaling of the Gastrointestinal Pathogen Salmonella enterica Serovar Typhimurium.Journal of innate immunity · 2022Review
- A Critical Review on Communication Mechanism within Plant-Endophytic Fungi Interactions to Cope with Biotic and Abiotic Stresses.Journal of fungi (Basel, Switzerland) · 2021Review
- Defeated by the nines: nine extracellular strategies to avoid microbe-associated molecular patterns recognition in plants.The Plant cell · 2021Article
- The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves.Nature microbiology · 2021Article
- Motility, Adhesion and c-di-GMP Influence the Endophytic Colonization of Rice byMicroorganisms · 2021Article
- Article
- Genetic factors involved in rhizosphere colonization by phytobeneficialComputational and structural biotechnology journal · 2020Review
- Pleiotropic Effects of c-di-GMP Content inApplied and environmental microbiology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs). This induces a defence response called pattern-triggered immunity (PTI) to fend off pathogen attack. Commensal bacteria are also exposed to potential immune recognition and must employ strategies to evade and/or suppress PTI to successfully colonize the plant. During plant infection, the flagellum has an ambiguous role, acting as both a virulence factor and also as a potent immunogen as a result of the recognition of its main building block, flagellin, by the plant pattern recognition receptors (PRRs), including FLAGELLIN SENSING2 (FLS2). Therefore, strict control of flagella synthesis is especially important for plant-associated bacteria. Here, we show that cyclic-di-GMP [bis-(3'-5')-cyclic di-guanosine monophosphate], a central regulator of bacterial lifestyle, is involved in the evasion of PTI. Elevated cyclic-di-GMP levels in the pathogen Pseudomonas syringae pv. tomato (Pto) DC3000, the opportunist P. aeruginosa PAO1 and the commensal P. protegens Pf-5 inhibit flagellin synthesis and help the bacteria to evade FLS2-mediated signalling in Nicotiana benthamiana and Arabidopsis thaliana. Despite this, high cellular cyclic-di-GMP concentrations were shown to drastically reduce the virulence of Pto DC3000 during plant infection. We propose that this is a result of reduced flagellar motility and/or additional pleiotropic effects of cyclic-di-GMP signalling on bacterial behaviour.
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