ArticleExperimental biology and medicine (Maywood, N.J.)2016
Low-dose irradiation affects the functional behavior of oral microbiota in the context of mucositis.
Article in Experimental biology and medicine (Maywood, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Using In Vitro Models to Study the Interactions Between Environmental Exposures and Human Microbiota.Microorganisms · 2025Review
- Correlation between gut microbiota characteristics and non-small cell lung cancer based on macrogenomics sequencing.Hereditas · 2024Article
- Probiotics in the management of radiation-induced oral mucositis.Frontiers in cellular and infection microbiology · 2024Review
- [Research Progress on the Protective Effect of Intestinal Flora on Radiation-induced Lung Injury in Thoracic Tumors].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Article
- Human gene and microbial analyses in rectal cancer complete responses to radiotherapy.BJS open · 2023Article
- The role of benzydamine in prevention and treatment of chemoradiotherapy-induced mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Synonymous point mutation of gtfB gene caused by therapeutic X-rays exposure reduced the biofilm formation and cariogenic abilities of Streptococcus mutans.Cell & bioscience · 2021Article
- Breakdown of Symbiosis in Radiation-Induced Oral Mucositis.Journal of fungi (Basel, Switzerland) · 2021Review
- The Effect of Radiation and Chemoradiation Therapy on the Head and Neck Mucosal Microbiome: A Review.Frontiers in oncology · 2021Review
- ProbioticFrontiers in immunology · 2021Article
- Microbiota in cancer development and treatment.Journal of cancer research and clinical oncology · 2019Review
- Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery.The British journal of surgery · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of host-microbe interactions in the pathobiology of oral mucositis is still unclear; therefore, this study aimed to unravel the effect of irradiation on behavioral characteristics of oral microbial species in the context of mucositis. Using various experimental in vitro setups, the effects of irradiation on growth and biofilm formation of two Candida spp., Streptococcus salivarius and Klebsiella oxytoca in different culture conditions were evaluated. Irradiation did not affect growth of planktonic cells, but reduced the number of K. oxytoca cells in newly formed biofilms cultured in static conditions. Biofilm formation of K. oxytoca and Candida glabrata was affected by irradiation and depended on the culturing conditions. In the presence of mucins, these effects were lost, indicating the protective nature of mucins. Furthermore, the Galleria melonella model was used to study effects on microbial virulence. Irradiated K. oxytoca microbes were more virulent in G. melonella larvae compared to the nonirradiated ones. Our data indicate that low-dose irradiation can have an impact on functional characteristics of microbial species. Screening for pathogens like K. oxytoca in the context of mucosits could be useful to allow early detection and immediate intervention.
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