Trial reportJournal of neuroengineering and rehabilitation2015
Robot-supported upper limb training in a virtual learning environment : a pilot randomized controlled trial in persons with MS.
Trial report in Journal of neuroengineering and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Robot-assisted Training on the Upper Limb in Persons With MS: an RCT
Intensity Dependent Clinical Effects of a Task-oriented Upper Limb Training in Multiple Sclerosis
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Virtual reality for multiple sclerosis rehabilitation.The Cochrane database of systematic reviews · 2025Pooled it
- Effect of Robot-Assisted Therapy on Participation of People with Limited Upper Limb Functioning: A Systematic Review with GRADE Recommendations.Occupational therapy international · 2021Pooled it
- What the Tech? The Management of Neurological Dysfunction Through the Use of Digital Technology.Advances in experimental medicine and biology · 2021Pooled it
- Markerless motion capture systems as training device in neurological rehabilitation: a systematic review of their use, application, target population and efficacy.Journal of neuroengineering and rehabilitation · 2017Pooled it
- Efficacy of a technology-based client-centred training system in neurological rehabilitation: a randomised controlled trial.Journal of neuroengineering and rehabilitation · 2021Trial
- Robot-Assisted Gravity Compensation for Upper Limb Motor Rehabilitation: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- A Robotic Assistance With Specialized Timing Improves Motor Performance: Implications for Movement Training.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- An Extensible Platform for Measurement and Modification of Muscle Engagement During Upper-Limb Robot-Facilitated Rehabilitation.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2025Article
- Shoulder Musculoskeletal Disorder Rehabilitation Using a Robotic Device Based on Electromyography (EMG) Biofeedback: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- Robotic systems for upper-limb rehabilitation in multiple sclerosis: a SWOT analysis and the synergies with virtual and augmented environments.Frontiers in robotics and AI · 2024Review
- A 3-DoF robotic platform for the rehabilitation and assessment of reaction time and balance skills of MS patients.PloS one · 2023Article
- The Design, Development, and Testing of a Virtual Reality Device for Upper Limb Training in People With Multiple Sclerosis: Single-Center Feasibility Study.JMIR serious games · 2022Article
- A Case Study of Upper Limb Robotic-Assisted Therapy Using the Track-Hold Device.Sensors (Basel, Switzerland) · 2022Article
- Adaptations in Muscular Strength for Individuals With Multiple Sclerosis Following Robotic Rehabilitation: A Scoping Review.Frontiers in rehabilitation sciences · 2022Article
- Upper Limb Sensory-Motor Control During Exposure to Different Mechanical Environments in Multiple Sclerosis Subjects With No Clinical Disability.Frontiers in neurorobotics · 2022Article
- THE EFFECTS OF EXERCISE TRAINING ON UPPER EXTREMITY FUNCTION FOR PERSONS WITH MULTIPLE SCLEROSIS: A SYSTEMATIC REVIEW.Journal of rehabilitation medicine. Clinical communications · 2022Review
- Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment.PloS one · 2022Article
- Motivation, Usability, and Credibility of an Intelligent Activity-Based Client-Centred Training System to Improve Functional Performance in Neurological Rehabilitation: An Exploratory Cohort Study.International journal of environmental research and public health · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the functional impact of upper limb dysfunction in multiple sclerosis (MS), effects of intensive exercise programs and specifically robot-supported training have been rarely investigated in persons with advanced MS.
aimTo investigate the effects of additional robot-supported upper limb training in persons with MS compared to conventional treatment only.
methodsSeventeen persons with MS (pwMS) (median Expanded Disability Status Scale of 8, range 3.5-8.5) were included in a pilot RCT comparing the effects of additional robot-supported training to conventional treatment only. Additional training consisted of 3 weekly sessions of 30 min interacting with the HapticMaster robot within an individualised virtual learning environment (I-TRAVLE). Clinical measures at body function (Hand grip strength, Motricity Index, Fugl-Meyer) and activity (Action Research Arm test, Motor Activity Log) level were administered before and after an intervention period of 8 weeks. The intervention group were also evaluated on robot-mediated movement tasks in three dimensions, providing active range of motion, movement duration and speed and hand-path ratio as indication of movement efficiency in the spatial domain. Non-parametric statistics were applied.
resultsPwMS commented favourably on the robot-supported virtual learning environment and reported functional training effects in daily life. Movement tasks in three dimensions, measured with the robot, were performed in less time and for the transporting and reaching movement tasks more efficiently. There were however no significant changes for any clinical measure in neither intervention nor control group although observational analyses of the included cases indicated large improvements on the Fugl-Meyer in persons with more marked upper limb dysfunction.
conclusionRobot-supported training lead to more efficient movement execution which was however, on group level, not reflected by significant changes on standard clinical tests. Persons with more marked upper limb dysfunction may benefit most from additional robot-supported training, but larger studies are needed.
trial registrationThis trial is registered within the registry Clinical Trials GOV ( NCT02257606 ).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.