Evidence map›Paper›PMID 26202157›Full record

ArticleMuscle & nerve2016

Magnetic stimulation supports muscle and nerve regeneration after trauma in mice.

Meline N L Stölting, Anne Sophie Arnold, Deana Haralampieva, Christoph Handschin, Tullio Sulser, Daniel Eberli

Registry-linked trialAbstract read
In one paragraph

Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03877640 (A Double-Blind, Sham Controlled Prospective Pilot Study of Urinary Stress Incontinence and Urgency in Women After 6 Treatments With HIFEM Technology), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03877640 naunknown statusnot on this mapstarted 2019, after this paper: background citation

A Double-Blind, Sham Controlled Prospective Pilot Study of Urinary Stress Incontinence and Urgency in Women After 6 Treatments With HIFEM Technology (BTL EMSELLA)

TypeinterventionalSponsorSan Diego Sexual MedicineRan2019 to 2024Enrolled21ConditionsStress Urinary Incontinence, Urge IncontinenceArmsBTL EMSELLA
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Skeletal Muscle Tissue Engineering: From Tissue Regeneration to Biorobotics.Cyborg and bionic systems (Washington, D.C.) · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Stem Cells in Functional Bladder Engineering.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Meline N L StöltingLaboratory for Urologic Tissue Engineering and Stem Cell Therapy, Division of Urology, University of Zurich, Frauenklinikstrasse 10, CH 8091, Zurich, Switzerland.
Anne Sophie ArnoldBiozentrum, Focal Area Growth and Development, University of Basel, Basel, Switzerland.
Deana HaralampievaLaboratory for Urologic Tissue Engineering and Stem Cell Therapy, Division of Urology, University of Zurich, Frauenklinikstrasse 10, CH 8091, Zurich, Switzerland.
Christoph HandschinBiozentrum, Focal Area Growth and Development, University of Basel, Basel, Switzerland.
Tullio SulserLaboratory for Urologic Tissue Engineering and Stem Cell Therapy, Division of Urology, University of Zurich, Frauenklinikstrasse 10, CH 8091, Zurich, Switzerland.
Daniel EberliLaboratory for Urologic Tissue Engineering and Stem Cell Therapy, Division of Urology, University of Zurich, Frauenklinikstrasse 10, CH 8091, Zurich, Switzerland.
Universitäts Frauenklinik · DEUniversity of Basel · CHUniversity of Zurich · CH

Funding

European Research Council 616830
6 · The paper itself

Abstract

introductionMagnetic stimulation (MS) has the ability to induce muscle twitch and has long been proposed as a therapeutic modality for skeletal muscle diseases. However, the molecular mechanisms underlying its means of action have not been defined.

methodsMuscle regeneration after trauma was studied in a standard muscle injury mouse model. The influence of MS on the formation of motor units, posttrauma muscle/nerve regeneration, and vascularization was investigated.

resultsWe found that MS does not cause systemic or muscle damage but improves muscle regeneration by significantly minimizing the presence of inflammatory infiltrate and formation of scars after trauma. It avoids posttrauma muscle atrophy, induces muscle hypertrophy, and increases the metabolism and turnover of muscle. It triples the expression of muscle markers and significantly improves muscle functional recovery after trauma.

conclusionsOur results indicate that MS supports muscle and nerve regeneration by activating muscle-nerve cross-talk and inducing the maturation of neuromuscular junctions.

Indexed as

AnimalsFemaleMagnetic Field TherapyMiceMice, Inbred C57BLMuscle ContractionMuscle, SkeletalMuscular AtrophyNerve RegenerationNeuromuscular JunctionOrgan Culture Techniquesmagnetic stimulation therapymuscle contractionnerve regenerationneuromuscular junctionrehabilitation outcome

Identifiers

PMID26202157
PMCPMC5130145
OpenAlexW1837966190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.