Evidence map›Paper›PMID 26202071›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015

Blood flow-restricted strength training displays high functional and biological efficacy in women: a within-subject comparison with high-load strength training.

Stian Ellefsen, Daniel Hammarström, Tor A Strand, Erika Zacharoff, Jon E Whist, Irene Rauk, Håvard Nygaard, Geir Vegge, Marita Hanestadhaugen, Mathias Wernbom and 4 more

Registry-linked trialOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07213726 (Quantification of Peripheral Hematopoietic Progenitor Cell Circulation Following Repeated Acute, Vascular Restriction Resistance Exercise Using the Delfi Tourniquet System), which is not on this map. Cited by 61 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 6 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07213726 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Quantification of Peripheral Hematopoietic Progenitor Cell Circulation Following Repeated Acute, Vascular Restriction Resistance Exercise Using the Delfi Tourniquet System

TypeinterventionalSponsorAndrews Research & Education FoundationRan2022 to 2026Enrolled15ConditionsBlood Flow Restriction (BFR) Training EffectsArmsDelfi Personalized Tourniquet System
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 6 syntheses or guidelines pooled it, 124 citations in OpenAlex.

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  5. Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods.International journal of environmental research and public health · 2019
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  11. Vitamin DJournal of cachexia, sarcopenia and muscle · 2021
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  12. The Acute Impact of External Compression on Back Squat Performance in Competitive Athletes.International journal of environmental research and public health · 2020
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Stian EllefsenLillehammer University College, Lillehammer, Norway; stian.ellefsen@hil.no.
Daniel HammarströmLillehammer University College, Lillehammer, Norway;
Tor A StrandInnlandet Hospital Trust, Lillehammer, Norway;
Erika ZacharoffLillehammer University College, Lillehammer, Norway;
Jon E WhistInnlandet Hospital Trust, Lillehammer, Norway;
Irene RaukInnlandet Hospital Trust, Lillehammer, Norway;
Håvard NygaardLillehammer University College, Lillehammer, Norway;
Geir VeggeLillehammer University College, Lillehammer, Norway;
Marita HanestadhaugenInnlandet Hospital Trust, Lillehammer, Norway;
Mathias WernbomLundberg Laboratory for Orthopaedic Research, Department of Orthopedics, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; and Center for Health and Performance, Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden.
Kristoffer T CummingNorwegian School of Sport Science, Oslo, Norway;
Roar RønningInnlandet Hospital Trust, Lillehammer, Norway;
Truls RaastadNorwegian School of Sport Science, Oslo, Norway;
Bent R RønnestadLillehammer University College, Lillehammer, Norway;
Innlandet Hospital Trust · NONorwegian School of Sport Sciences · NOUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited data exist on the efficacy of low-load blood flow-restricted strength training (BFR), as compared directly to heavy-load strength training (HST). Here, we show that 12 wk of twice-a-week unilateral BFR [30% of one repetition maximum (1RM) to exhaustion] and HST (6-10RM) of knee extensors provide similar increases in 1RM knee extension and cross-sectional area of distal parts of musculus quadriceps femoris in nine untrained women (age 22 ± 1 yr). The two protocols resulted in similar acute increases in serum levels of human growth hormone. On the cellular level, 12 wk of BFR and HST resulted in similar shifts in muscle fiber composition in musculus vastus lateralis, evident as increased MyHC2A proportions and decreased MyHC2X proportions. They also resulted in similar changes of the expression of 29 genes involved in skeletal muscle function, measured both in a rested state following 12 wk of training and subsequent to singular training sessions. Training had no effect on myonuclei proportions. Of particular interest, 1) gross adaptations to BFR and HST were greater in individuals with higher proportions of type 2 fibers, 2) both BFR and HST resulted in approximately four-fold increases in the expression of the novel exercise-responsive gene Syndecan-4, and 3) BFR provided lesser hypertrophy than HST in the proximal half of musculus quadriceps femoris and also in CSApeak, potentially being a consequence of pressure from the tourniquet utilized to achieve blood flow restriction. In conclusion, BFR and HST of knee extensors resulted in similar adaptations in functional, physiological, and cell biological parameters in untrained women.

Indexed as

Anatomy, Cross-SectionalBiopsyCell CountFemaleGene ExpressionHormonesHumansImmunohistochemistryLegMagnetic Resonance ImagingMuscle Fibers, SkeletalMuscle, SkeletalMuscle StrengthRegional Blood FlowResistance TrainingRNA, MessengerHormonesRNA, Messengergene expressionheavy-load strength traininglow-load blood flow-restricted trainingmuscle fibermuscle strength and mass

Identifiers

PMID26202071
PMCPMC4666930
OpenAlexW2178532708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.