Evidence map›Paper›PMID 26201973›Full record

ArticleJournal of comparative effectiveness research2015

Observational methods to assess the effectiveness of screening colonoscopy in reducing right colon cancer mortality risk: SCOLAR.

Michael Goodman, Robert H Fletcher, V Paul Doria-Rose, Christopher D Jensen, Alexis M Zebrowski, Tracy A Becerra, Virginia P Quinn, Ann G Zauber, Douglas A Corley, Chyke A Doubeni

Open access · greenAbstract read
In one paragraph

Article in Journal of comparative effectiveness research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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  16. Advancing methods for US transgender health research.Current opinion in endocrinology, diabetes, and obesity · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Michael GoodmanDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Robert H FletcherDepartment of Population Health, Harvard Medical School, Boston, MA 02115, USA.
V Paul Doria-RoseDivision of Cancer Control & Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
Christopher D JensenDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Alexis M ZebrowskiDepartment of Family Medicine & Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tracy A BecerraDepartment of Research & Evaluation, Kaiser Permanente, Pasadena, CA 91107, USA.
Virginia P QuinnDepartment of Research & Evaluation, Kaiser Permanente, Pasadena, CA 91107, USA.
Ann G ZauberDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Douglas A CorleyDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Chyke A DoubeniDepartment of Family Medicine & Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kaiser Permanente · USUniversity of Pennsylvania · USEmory University · USHarvard University · USMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Effectiveness of Screening Colonoscopy in Reducing Deaths from Colorectal CancerU01CA151736 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DOUBENI, CHYKE ABADAMA · 2011 to 2015
$4.5M
Effectiveness of Screening Colonoscopy in Reducing Deaths from Colorectal CancerR01CA151736 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DOUBENI, CHYKE ABADAMA · 2010 to 2010
$491k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA151736NCI NIH HHS U01 CA151736
6 · The paper itself

Abstract

aimsScreening colonoscopy's effectiveness in reducing risk of death from right colon cancers remains unclear. Methodological challenges of existing observational studies addressing this issue motivated the design of 'Effectiveness of Screening for Colorectal Cancer in Average-Risk Adults (SCOLAR)'.

methodsSCOLAR is a nested case-control study based on two large integrated health systems. This affords access to a large, well-defined historical cohort linked to integrated data on cancer outcomes, patient eligibility, test indications and important confounders.

resultsWe found electronic data adequate for excluding ineligible patients (except family history), but not the detailed information needed for test indication assignment.

conclusionThe lessons of SCOLAR's design and implementation may be useful for future studies seeking to evaluate the effectiveness of screening tests in community settings.

Indexed as

Early Detection of CancerAgedCase-Control StudiesColonoscopyColorectal NeoplasmsFemaleHumansMaleObservationRiskUnited Statescancer screeningcase–control studycolorectal cancerselection bias

Identifiers

PMID26201973
PMCPMC4666780
OpenAlexW1803945557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.