ArticleHepatology international2013
Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors.
Article in Hepatology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Functional mouse hepatocytes derived from interspecies chimeric livers effectively mitigate chronic liver fibrosis.Stem cell reports · 2024Article
- Restored glyoxylate metabolism after AGXT gene correction and direct reprogramming of primary hyperoxaluria type 1 fibroblasts.iScience · 2024Article
- A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies.Stem cell research & therapy · 2023Article
- Somatic Lineage Reprogramming.Cold Spring Harbor perspectives in biology · 2022Review
- Phenotypical, functional and transcriptomic comparison of two modified methods of hepatocyte differentiation from human induced pluripotent stem cells.Biomedical reports · 2022Article
- Progress and Challenges in the Use of a Liver-on-a-Chip for Hepatotropic Infectious Diseases.Micromachines · 2021Review
- Review
- KinderMiner Web: a simple web tool for ranking pairwise associations in biomedical applications.F1000Research · 2020Article
- A serum-free medium suitable for maintaining cell morphology and liver-specific function in induced human hepatocytes.Cytotechnology · 2019Article
- Direct cell reprogramming for tissue engineering and regenerative medicine.Journal of biological engineering · 2019Review
- Generation of non-viral, transgene-free hepatocyte like cells with piggyBac transposon.Scientific reports · 2017Article
- A Simple Text Mining Approach for Ranking Pairwise Associations in Biomedical Applications.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2017Article
- Computational methods for direct cell conversion.Cell cycle (Georgetown, Tex.) · 2016Review
- A predictive computational framework for direct reprogramming between human cell types.Nature genetics · 2016Article
- Cell therapy from bench to bedside: Hepatocytes from fibroblasts - the truth and myth of transdifferentiation.World journal of gastroenterology · 2015Review
- Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control.Clinical and translational medicine · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLiver transplantation is currently the only curative therapeutic option for end-stage liver cirrhosis. However, due to the limitations of donor liver availability and occasional rejection, it cannot always be successfully applied. In this study, we determined whether fibroblasts can be transdifferentiated into hepatocyte-like cells by transcription factors that initiate and maintain hepatocyte differentiation.
methodsFibroblasts were transduced with retrovirus vectors carrying FOXA2, HNF4α, and C/EBPβ. To enhance the efficiency of transdifferentiation, cMyc was also expressed.
resultsTransdifferentiation was successful using both neonatal fibroblasts and human forehead fibroblasts. The transdifferentiated cells produced hepatocyte-specific proteins such as albumin and cytochrome, and had important hepatocyte-specific functions, such as glycogen storage and indocyanine green uptake, suggesting that the cells function at least as partial hepatocytes.
conclusionsThese results provide a novel method of generating differentiated hepatocyte-like cells, and may represent an alternative source of cells for future cell-based therapeutics for end-stage liver diseases.
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Registered trials
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