ArticleHepatology international2013
Autoimmune hepatitis: the role of environmental risk factors: a population-based study.
Article in Hepatology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Autoimmune Hepatitis: A Review of Molecular Mechanisms and Research Gaps in African Populations.Biology · 2026Review
- The Geoepidemiology of Autoimmune Hepatitis.Clinical reviews in allergy & immunology · 2026Review
- Alcohol Consumption and Autoimmune Diseases.International journal of molecular sciences · 2025Review
- Global incidence and prevalence of autoimmune hepatitis, 1970-2022: a systematic review and meta-analysis.EClinicalMedicine · 2023Article
- Autoimmune hepatitis presenting with concomitant chronic pancreatitis.Radiology case reports · 2023Article
- Binge drinking does not appear to have an adverse effect on non-alcoholic fatty liver disease: Findings from a study of four First Nations communities.Canadian liver journal · 2023Article
- The progress of autoimmune hepatitis research and future challenges.Open medicine (Warsaw, Poland) · 2023Review
- The intestinal and biliary microbiome in autoimmune liver disease-current evidence and concepts.Seminars in immunopathology · 2022Review
- Patients with Autoimmune Hepatitis Report Lower Lifetime Coffee Consumption.Digestive diseases and sciences · 2022Article
- CCN1 Promotes Inflammation by Inducing IL-6 ProductionFrontiers in immunology · 2022Article
- Environmental risk factors are associated with autoimmune hepatitis.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- Impact of genetic and environmental factors on autoimmune hepatitis.Journal of translational autoimmunity · 2021Review
- The effects of binge drinking on healthy and diseased livers.Canadian liver journal · 2021Review
- Diffuse Systemic Sclerosis in a Patient with Primary Biliary Cirrhosis and Autoimmune Hepatitis Overlap Syndrome: A Case Report.Annals of dermatology · 2020Article
- Familial associations between autoimmune hepatitis and primary biliary cholangitis and other autoimmune diseases.PloS one · 2020Article
- Regulatory T Cells in Autoimmune Hepatitis: Unveiling Their Roles in Mouse Models and Patients.Frontiers in immunology · 2020Review
- Genetic and Environmental Risk Factors for Autoimmune Hepatitis.Clinical liver disease · 2019Review
- Extrahepatic Autoimmune Diseases are Prevalent in Autoimmune Hepatitis Patients and Their First-Degree Relatives: Survey Study.Interactive journal of medical research · 2018Article
- Autoimmune Hepatitis in the East and the West.Inflammatory intestinal diseases · 2017Article
- Alcohol Consumption in Concomitant Liver Disease: How Much is Too Much?Current hepatology reports · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe etiology of autoimmune hepatitis (AIH) likely involves a complex interaction of genetic and environmental factors. We aim to investigate the associations between exposure to putative environmental factors and AIH and to quantify AIH risk in a first-degree relative.
methodsWe conducted a population-based case-control study. Cases were AIH patients who were alive and resided in Canterbury, New Zealand, between 1 July 2011 and 30 June 2012. Controls were randomly selected from the Electoral Roll and were matched 2:1 to each case by age and gender. Self-reporting questionnaires that cover lifestyle factors, childhood factors and family history were used.
results72 AIH cases and 144 controls were included. We found that exposure to antibiotics within 12 months prior to AIH diagnosis (OR 12.98, 95 % CI 2.49-67.67, p < 0.01) was an independent risk factor for the development of AIH. Alcohol consumption (OR 0.43, 95 % CI 0.28-0.68, p < 0.01) and childhood home with wood heating (OR 0.30, 95 % CI 0.14-0.63, p < 0.01) were independently associated with reduced risks of later development of AIH. The crude risk of AIH in first-degree relatives of a patient with AIH was 0.2 % (95 % CI <0.1-2.0).
conclusionsWe found that antibiotics are an independent risk factor for the development of AIH, whereas alcohol consumption and living in a childhood home with wood heating are independent protective factors against the later development of AIH.
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26201924What OpenQuestion holds
Registered trials
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