ArticleBMC complementary and alternative medicine2015
Antioxidant effects of Dendropanax morbifera Léveille extract in the hippocampus of mercury-exposed rats.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Unifying Phytochemistry, Analytics, and Target Prediction to AdvanceLife (Basel, Switzerland) · 2026Review
- Therapeutic potential of traditional herbal plants and their polyphenols in alleviation of mercury toxicity.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The Neuroprotective Effects ofInternational journal of molecular sciences · 2023Article
- Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals.Archives of toxicology · 2022Review
- Dihydroconiferyl Ferulate Isolated fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Comprehensive Review Regarding Mercury Poisoning and Its Complex Involvement in Alzheimer's Disease.International journal of molecular sciences · 2022Review
- DHA ameliorates MeHg‑induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway.Molecular medicine reports · 2021Article
- Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms ofAntioxidants (Basel, Switzerland) · 2021Article
- The γ-Benzylidene Digoxin Derivative BD-15 Increases the α3-Na, K-ATPase Activity in Rat Hippocampus and Prefrontal Cortex and no Change on Heart.The Journal of membrane biology · 2021Article
- Antihyperuricemic Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Dendropanax Morbiferus and Other Species from the Genus Dendropanax: Therapeutic Potential of Its Traditional Uses, Phytochemistry, and Pharmacology.Antioxidants (Basel, Switzerland) · 2020Review
- The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?Oxidative medicine and cellular longevity · 2020Review
- Article
- Leaf extracts from Dendropanax morbifera Léveille mitigate mercury-induced reduction of spatial memory, as well as cell proliferation, and neuroblast differentiation in rat dentate gyrus.BMC complementary and alternative medicine · 2019Article
- Protective Effects ofToxicological research · 2019Article
- Medicinal plants and natural products can play a significant role in mitigation of mercury toxicity.Interdisciplinary toxicology · 2018Review
- Development and Validation of a HPLC-UV Method for Extraction Optimization and Biological Evaluation of Hot-Water and Ethanolic Extracts of Dendropanax morbifera Leaves.Molecules (Basel, Switzerland) · 2018Article
- Polyacetylene FromFrontiers in pharmacology · 2018Article
- Aqueous Extract ofOxidative medicine and cellular longevity · 2018Article
- Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDendropanax morbifera Léveille has been employed for the treatment of infectious diseases using folk medicine. In this study, we evaluated the antioxidant effects of a leaf extract of Dendropanax morbifera Léveille in the hippocampus of mercury-exposed rats.
methodsSeven-week-old Sprague-Dawley rats received a daily intraperitoneal injection of 5 μg/kg dimethylmercury and/or oral Dendropanax morbifera Léveille leaf extract (100 mg/kg) for 4 weeks. Animals were sacrificed 2 h after the last dimethylmercury and/or leaf extract treatment. Mercury levels were measured in homogenates of hippocampal tissue, a brain region that is vulnerable to mercury toxicity. In addition, we measured reactive oxygen species production, lipid peroxidation levels, and antioxidant levels in these hippocampal homogenates.
resultsTreatment with Dendropanax morbifera Léveille leaf extract significantly reduced mercury levels in hippocampal homogenates and attenuated the dimethylmercury-induced increase in the production of reactive oxygen species and formation of malondialdehyde. In addition, this leaf extract treatment significantly reversed the dimethylmercury-induced reduction in the hippocampal activities of Cu, Zn-superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase.
conclusionThese results suggest that a leaf extract of Dendropanax morbifera Léveille had strong antioxidant effects in the hippocampus of mercury-exposed rats.
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