Evidence map›Paper›PMID 26201839›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2015

The Role of Metabolomics in Brain Metabolism Research.

Julijana Ivanisevic, Gary Siuzdak

Abstract read
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  9. Article
  10. Article
  11. In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Metabolite Profile Changes in Different Regions of Rat Brain Affected byEvidence-based complementary and alternative medicine : eCAM · 2020
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julijana IvanisevicScripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Gary Siuzdak

Funding

Pharmacokinetics and Drug-Drug InteractionsP01DA028555 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BOSKA, MICHAEL DOUGLAS · 2010 to 2019
$16.8M
Normalizing Breast Cancer Metabolism to Prevent Progression and Recurrence (PQ21)R01CA170737 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI FELDING, BRUNIE H. · 2012 to 2015
$2.1M
XCMS Metabolomic Data TechnologyR01GM114368 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SIUZDAK, GARY E · 2015 to 2018
$1.5M
NCI NIH HHS R01 CA170737NCI NIH HHS R01 CA170737-02NIDA NIH HHS 2P01DA028555-06NIDA NIH HHS P01 DA028555NIGMS NIH HHS R01 GM114368NIGMS NIH HHS R01 GM114368-02
6 · The paper itself

Abstract

This special edition of the Journal of Neuroimmune Pharmacology focuses on the leading edge of metabolomics in brain metabolism research. The topics covered include a metabolomic field overview and the challenges in neuroscience metabolomics. The workflow and utility of different analytical platforms to profile complex biological matrices that include biofluids, brain tissue and cells, are shown in several case studies. These studies demonstrate how global and targeted metabolite profiling can be applied to distinguish disease stages and to understand the effects of drug action on the central nervous system (CNS). Finally, we discuss the importance of metabolomics to advance the understanding of brain function that includes ligand-receptor interactions and new insights into the mechanisms of CNS disorders.

Indexed as

MetabolomicsBrainBrain DiseasesHumans

Identifiers

PMID26201839
PMCPMC4546538

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.