Evidence map›Paper›PMID 26201787›Full record

ArticleHepatology international2013

High alanine aminotransferase level as a predictor for the incidence of macrovascular disease in type 2 diabetic patients with fatty liver disease.

Megumi Inoue, Junya Oribe, Masataka Seike, Takayuki Masaki, Mizuki Endo, Masanori Tokoro, Mie Yoshihara, Koichi Honda, Rie Shin, Katsunari Abe and 2 more

Abstract read
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In one paragraph

Article in Hepatology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Megumi InoueDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan. meg8577@oita-u.ac.jp.
Junya OribeDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Masataka SeikeDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Takayuki MasakiDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Mizuki EndoDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Masanori TokoroDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Mie YoshiharaDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Koichi HondaDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Rie ShinDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Katsunari AbeAbe Clinic, 16-13, Nakakasuga, Oita, Oita, 870-0039, Japan.
Nobuyuki AbeAbe Clinic, 16-13, Nakakasuga, Oita, Oita, 870-0039, Japan.
Hironobu YoshimatsuDepartment of Internal Medicine 1, Faculty of Medicine, Oita University, 1-1, Idaigaoka, Yufu, Oita, 879-5593, Japan.
Oita University · JPOita Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe investigated whether fatty liver (FL) disease in type 2 diabetic mellitus (T2DM) patients affects their incidence of macrovascular disease. In addition, we detected a useful marker for predicting the incidence of macrovascular disease events.

methodsA total of 458 patients who underwent abdominal ultrasonography (US) between April 2003 and March 2004 in a diabetic clinic were divided into FL (n = 211) and non-FL (NFL; n = 247) groups, and followed by a diabetologist and/or hepatologist for 5 years.

resultsNo significant difference in the incidence of macrovascular disease, neither cerebrovascular disease nor coronary heart disease, was observed between FL and NFL patients. Interestingly, in FL diabetic patients, only an alanine aminotransferase (ALT) level ≥30 IU/l was significantly associated with the incidence of macrovascular events in univariate (odds ratio [OR], 10.632; 95 % confidence interval [CI], 1.302-86.841; p = 0.0274) and multivariate (OR, 10.134; CI 1.223-83.995; p = 0.0318) analyses. Patients with higher ALT levels had a higher cumulative incidence of macrovascular disease events than did those with lower ALT levels (p = 0.0068). In conclusion, an ALT level ≥30 IU/l is an independent risk indicator of macrovascular disease in diabetic patients with FLD, whereas the presence of FL itself in T2DM patients is not associated with an increased incidence of macrovascular events.

conclusionsOur findings indicate that therapeutic interventions may be necessary for FL patients with high ALT levels to prevent macrovascular disease.

Indexed as

Alanine aminotransferaseDiabetesFatty liver diseaseMacrovascular disease

Identifiers

PMID26201787
OpenAlexW2079703888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.