Trial reportJournal of the American Geriatrics Society2015
Functional Impairments Mediate Association Between Clinical Fracture Risk and Type 2 Diabetes Mellitus in Older Women.
Trial report in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Diabetes mellitus is a risk factor for low bone mass-related fractures: A meta-analysis of cohort studies.Medicine · 2017Pooled it
- Secondary fracture rates and risk factors 1 year after a proximal femoral fracture under FLS.Journal of bone and mineral metabolism · 2023Article
- Influence of type 2 diabetes microangiopathy on bone mineral density and bone metabolism: A meta-analysis.Heliyon · 2022Article
- Effect of inflammation on bones in diabetic patients with periodontitis via RANKL/OPG system-A review.Journal of diabetes and metabolic disorders · 2022Review
- Systematic Review: Are the Elderly With Diabetes Mellitus Type 2 Prone to Fragility Fractures?Cureus · 2021Review
- Severe central obesity or diabetes can replace weight loss in the detection of frailty in obese younger elderly - a preliminary study.Clinical interventions in aging · 2018Article
- Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications.The Journal of clinical endocrinology and metabolism · 2018Article
- Initiation of antihypertensive monotherapy and incident fractures among Medicare beneficiaries.Injury epidemiology · 2017Article
- Fracture Rates and Bone Density Among Postmenopausal Veteran and Non-Veteran Women From the Women's Health Initiative.The Gerontologist · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesTo examine the effect of functional impairments in older women with diabetes mellitus (DM) on incident clinical fractures.
designSecondary analysis of two large prospective cohort studies.
settingNorth Carolina Established Populations for Epidemiologic Studies of the Elderly (EPESE) and Women's Health Initiative (WHI) clinical trials.
participantsEPESE included 2,704 community-dwelling women aged 65 and older; WHI clinical trials included 68,125 postmenopausal women. MEASUREMENTS: Women with DM at baseline were compared with women without in successive Cox proportional hazards models. Functional limitations were determined according to self-reported difficulties with activities of daily living (ADLs) and physical activities.
resultsThe risk of any clinical fracture during the study period was greater in women with DM, after controlling for age, race and ethnicity, and body mass index, in the EPESE (hazard ratio (HR) = 1.36, 95% confidence interval (CI) = 1.08-1.72) and WHI (HR = 1.29, 95% CI = 1.19-1.39) cohorts. After inclusion of functional limitations, the greater risk of fracture associated with DM decreased in the EPESE (HR = 1.25, 95% CI = 0.98-1.59) and WHI (HR = 1.21, 95% CI = 1.12-1.31) cohorts. In participants with DM, difficulties with moderate physical activities, such as bending or stooping, walking several blocks, and heavy housework, were significantly associated with incident fracture (P < .05).
conclusionOlder women with DM are at greater risk of clinical fractures than those without, independent of bone mineral density. Greater functional impairment in moderate physical activities mediates this greater fracture risk in part, although there remains an unexplained residual DM-associated risk for fracture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.