ArticleJournal of anatomy2015
An anatomical study of porcine peripheral nerve and its potential use in nerve tissue engineering.
Article in Journal of anatomy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- A Systematic Review of the Tensile Biomechanical Properties of the Neonatal Brachial Plexus.Journal of biomechanical engineering · 2021Pooled it
- Long-term exploratory evaluation of an acellular biomimetic polyfascicular nerve guidance conduit for peripheral nerve repair in a rhesus macaque model.Bioactive materials · 2027Article
- Establishment of a novel deep learning-based method for gait analysis after peripheral nerve injury in pigs.Regenerative therapy · 2026Article
- The extracellular matrix in peripheral nerve repair and regeneration: a narrative review of its role and therapeutic potential.Frontiers in neuroanatomy · 2025Review
- [Research progress of silk-based biomaterials for peripheral nerve regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- Scaffold design considerations for peripheral nerve regeneration.Journal of neural engineering · 2024Review
- Cell Heterogeneity and Variability in Peripheral Nerve after Injury.International journal of molecular sciences · 2024Review
- Exploring an innovative decellularization protocol for porcine nerve grafts: a translational approach to peripheral nerve repair.Frontiers in neuroanatomy · 2024Article
- Some Mechanical Constraints to the Biomimicry with Peripheral Nerves.Biomimetics (Basel, Switzerland) · 2023Article
- In vivo biomechanical responses of neonatal brachial plexus when subjected to stretch.PloS one · 2023Article
- Acellular nerve xenografts based on supercritical extraction technology for repairing long-distance sciatic nerve defects in rats.Bioactive materials · 2022Article
- An In Vitro Study to Investigate Biomechanical Responses of Peripheral Nerves in Hypoxic Neonatal Piglets.Journal of biomechanical engineering · 2021Article
- Cutaneous innervation in impaired diabetic wound healing.Translational research : the journal of laboratory and clinical medicine · 2021Review
- Safety and efficacy of a nerve matrix membrane as a collagen nerve wrapping: a randomized, single-blind, multicenter clinical trial.Neural regeneration research · 2021Article
- Decellularized peripheral nerve grafts by a modified protocol for repair of rat sciatic nerve injury.Neural regeneration research · 2021Article
- Xenogeneic Decellularized Extracellular Matrix-based Biomaterials For Peripheral Nerve Repair and Regeneration.Current neuropharmacology · 2021Review
- Effects of Chemical and Radiation Sterilisation on the Biological and Biomechanical Properties of Decellularised Porcine Peripheral Nerves.Frontiers in bioengineering and biotechnology · 2021Article
- Quantified Morphology of the Cervical and Subdiaphragmatic Vagus Nerves of Human, Pig, and Rat.Frontiers in neuroscience · 2020Article
- Machine intelligence for nerve conduit design and production.Journal of biological engineering · 2020Review
- Fabrication and Evaluation of a Xenogeneic Decellularized Nerve-Derived Material: Preclinical Studies of a New Strategy for Nerve Repair.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Current nerve tissue engineering applications are adopting xenogeneic nerve tissue as potential nerve grafts to help aid nerve regeneration. However, there is little literature that describes the exact location, anatomy and physiology of these nerves to highlight their potential as a donor graft. The aim of this study was to identify and characterise the structural and extracellular matrix (ECM) components of porcine peripheral nerves in the hind leg. Methods included the dissection of porcine nerves, localisation, characterisation and quantification of the ECM components and identification of nerve cells. Results showed a noticeable variance between porcine and rat nerve (a commonly studied species) in terms of fascicle number. The study also revealed that when porcine peripheral nerves branch, a decrease in fascicle number and size was evident. Porcine ECM and nerve fascicles were found to be predominately comprised of collagen together with glycosaminoglycans, laminin and fibronectin. Immunolabelling for nerve growth factor receptor p75 also revealed the localisation of Schwann cells around and inside the fascicles. In conclusion, it is shown that porcine peripheral nerves possess a microstructure similar to that found in rat, and is not dissimilar to human. This finding could extend to the suggestion that due to the similarities in anatomy to human nerve, porcine nerves may have utility as a nerve graft providing guidance and support to regenerating axons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.