Evidence map›Paper›PMID 26200920›Full record

ArticleChemistry and physics of lipids2016

Synthesis and photochemical properties of PEGylated coumarin-caged ceramides for cell studies.

Young Ah Kim, Jenna Day, Carol Ann Lirette, Willard J Costain, Linda J Johnston, Robert Bittman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry and physics of lipids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Synthetic Lipid Biology.Chemical reviews · 2025
    Review
  2. Caged lipids for subcellular manipulation.Current opinion in chemical biology · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Young Ah KimDepartment of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, NY 11367, USA. Electronic address: Youngah.Kim@qc.cuny.edu.
Jenna DayNational Research Council of Canada, Ottawa, ON K1A 0R6, Canada; Department of Chemistry, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Carol Ann LiretteNational Research Council of Canada, Ottawa, ON K1A 0R6, Canada; Department of Chemistry, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Willard J CostainNational Research Council of Canada, Ottawa, ON K1A 0R6, Canada.
Linda J JohnstonNational Research Council of Canada, Ottawa, ON K1A 0R6, Canada.
Robert BittmanDepartment of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, NY 11367, USA.
National Research Council Canada · CAQueens College, CUNY · US

Funding

Synthesis of Novel Bioactive Sphingolipids as a ResourceR24HL083187 · NHLBI · QUEENS COLLEGE · PI BITTMAN, ROBERT · 2006 to 2013
$2.5M
NHLBI NIH HHS HL-08317NHLBI NIH HHS R24 HL083187
6 · The paper itself

Abstract

Caged ceramide analogues (C6-, C16-, C18-, C22- and C24-Cer) have been prepared by introducing a hydrophilic coumarin-based cage bearing a short polyethylene glycol (PEG) chain. (6-Bromo-7-mTEGylated-coumarin-4-yl)methyl (Btc) caged ceramide showed efficient photo-uncaging to release the parent ceramide upon direct exposure to 350 nm UV light; in contrast (7-mTEGylated-coumarin-4-yl)methyl (Tc) caged ceramide was photolysed more slowly. In preliminary experiments, Btc-caged ceramides were taken up by cells and their photolysis led to decreases in cell viability, but not to activation of caspase enzymes, suggesting that either reactive oxygen species or an alternate caspase-independent pathway may be responsible for the decreases in cell viability caused by photolysis of caged ceramides.

Indexed as

Ultraviolet RaysCaspasesCell SurvivalCeramidesCoumarinsHeLa CellsHumansMolecular StructurePhotolysisPolyethylene GlycolsReactive Oxygen SpeciesStructure-Activity RelationshipTumor Cells, CulturedCaspasesCeramidesCoumarinsPolyethylene GlycolsReactive Oxygen SpeciesCeramidePEGylated coumarin cagesPhotocagePhotolysis

Identifiers

PMID26200920
PMCPMC4718835
OpenAlexW968303433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.