ArticleCortex; a journal devoted to the study of the nervous system and behavior2015
Atypical processing of voice sounds in infants at risk for autism spectrum disorder.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Neurobiology of language in autism: a systematic review of pediatric studies.Brain imaging and behavior · 2026Pooled it
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Neural correlates and predictors of speech and language development in infants at elevated likelihood for autism: a systematic review.Frontiers in human neuroscience · 2023Pooled it
- The Value of Brain Imaging and Electrophysiological Testing for Early Screening of Autism Spectrum Disorder: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Is infant neural sensitivity to vocal emotion associated with mother-infant relational experience?PloS one · 2019Trial
- Early detection of distinct language development in infants of mothers with severe mental illness using fNIRS.Communications psychology · 2026Article
- Reward-related language processing of maternal speech in infants at different likelihood of ASD.Social cognitive and affective neuroscience · 2026Article
- Characteristic parameter analysis of magnetic resonance diffusion tensor imaging in children with autism spectrum disorder: a retrospective study.BMC pediatrics · 2025Article
- Early neurophysiological markers of aberrant auditory processing associated with increased risk of autism spectrum disorder: A systematic review.Pediatric investigation · 2025Review
- Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development.Developmental cognitive neuroscience · 2025Review
- Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism.Molecular autism · 2025Article
- Specialization of the brain for language in children with Fragile X Syndrome: a functional Near Infrared Spectroscopy study.Journal of neurodevelopmental disorders · 2024Article
- Atypical Neural Responses to Native and Non-Native Language in Infants at High Likelihood for Developing Autism.Research square · 2024Article
- Article
- Perception and adaptation of receptive prosody in autistic adolescents.Scientific reports · 2024Article
- Unveiling the development of human voice perception: Neurobiological mechanisms and pathophysiology.Current research in neurobiology · 2024Review
- A Developmental Social Neuroscience Perspective on Infant Autism Interventions.Annual review of developmental psychology · 2023Article
- Baby Brains at Work: How Task-Based Functional Magnetic Resonance Imaging Can Illuminate the Early Emergence of Psychiatric Risk.Biological psychiatry · 2023Review
- Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder: Pathogenesis and Therapeutic Implications.Current neuropharmacology · 2023Review
- Atypical cerebellar functional connectivity at 9 months of age predicts delayed socio-communicative profiles in infants at high and low risk for autism.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Adults diagnosed with autism spectrum disorder (ASD) show a reduced sensitivity (degree of selective response) to social stimuli such as human voices. In order to determine whether this reduced sensitivity is a consequence of years of poor social interaction and communication or is present prior to significant experience, we used functional MRI to examine cortical sensitivity to auditory stimuli in infants at high familial risk for later emerging ASD (HR group, N = 15), and compared this to infants with no family history of ASD (LR group, N = 18). The infants (aged between 4 and 7 months) were presented with voice and environmental sounds while asleep in the scanner and their behaviour was also examined in the context of observed parent-infant interaction. Whereas LR infants showed early specialisation for human voice processing in right temporal and medial frontal regions, the HR infants did not. Similarly, LR infants showed stronger sensitivity than HR infants to sad vocalisations in the right fusiform gyrus and left hippocampus. Also, in the HR group only, there was an association between each infant's degree of engagement during social interaction and the degree of voice sensitivity in key cortical regions. These results suggest that at least some infants at high-risk for ASD have atypical neural responses to human voice with and without emotional valence. Further exploration of the relationship between behaviour during social interaction and voice processing may help better understand the mechanisms that lead to different outcomes in at risk populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.