ArticleBiophysical journal2015
Calcium ions modulate the mechanics of tomato bushy stunt virus.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Protocol for AFM Nanoindentation of Viruses and Protein Cages.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Viruses under mechanical force: Implications and applications.Virus research · 2026Review
- Structural Polymorphs of Self-Assembled Brome Mosaic Virus Capsid Protein.The journal of physical chemistry. B · 2026Article
- Tomato Bushy Stunt Virus (TBSV): From a Plant Pathogen to a Multifunctional Biotechnology Platform.Viruses · 2025Review
- Calcium signaling: an emerging player in plant antiviral defense.Journal of experimental botany · 2024Article
- An Observation of a Very High Swelling of Bromovirus Members at Specific Ionic Strengths and pH.Viruses · 2023Article
- The diversity of protein-protein interaction interfaces within T=3 icosahedral viral capsids.Frontiers in molecular biosciences · 2022Article
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- Article
- Effect of dsDNA on the Assembly Pathway and Mechanical Strength of SV40 VP1 Virus-like Particles.Biophysical journal · 2018Article
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- Electrostatics-Driven Inflation of Elastic Icosahedral Shells as a Model for Swelling of Viruses.Biophysical journal · 2018Article
- Exploring the role of genome and structural ions in preventing viral capsid collapse during dehydration.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Cargo-shell and cargo-cargo couplings govern the mechanics of artificially loaded virus-derived cages.Nanoscale · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral particles are endowed with physicochemical properties whose modulation confers certain metastability to their structures to fulfill each task of the viral cycle. Here, we investigate the effects of swelling and ion depletion on the mechanical stability of individual tomato bushy stunt virus nanoparticles (TBSV-NPs). Our experiments show that calcium ions modulate the mechanics of the capsid: the sequestration of calcium ions from the intracapsid binding sites reduces rigidity and resilience in ∼24% and 40%, respectively. Interestingly, mechanical deformations performed on native TBSV-NPs induce an analogous result. In addition, TBSV-NPs do not show capsomeric vacancies after surpassing the elastic limit. We hypothesize that even though there are breakages among neighboring capsomers, RNA-capsid protein interaction prevents the release of capsid subunits. This work shows the mechanical role of calcium ions in viral shell stability and identifies TBSV-NPs as malleable platforms based on protein cages for cargo transportation at the nanoscale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.